Derm path DSA Flashcards
major functions of skin
protective covering
tactile interaction
body temp regulation
how does skin fucntion as part of immune system
production of cytokines and defensins
Ag presentation via Langerhans Epidermal Dendritic Cells and possibly dermal dendrocytes
organization of skin
epidermis
dermis
subcutis
what are the 2 types of dermis
papillary dermis and reticular dermis
what are the adnexal structural units of the skin
pilar (hair) units
eccrine units
apocrine units
what are the pilar units of skin
pilosebaceous units, arrector pili muscles
what are the eccrine units of skin
eccrine glands and ducts
what are the apocrine unites of skin
apocrine glands and ducts
where is papillary dermis
right beneath the dermal epidermal jucntion
what are the stratums of skin in order from most superficial to deep
stratum corneum stratum lucidum stratum granulosum stratum spinosum stratum basale
what is a sebaceous gland
oil gland
what is an eccrine gland
sweat gland
where are the apocrine glands located
deep dermis and often at junction of reticular dermis and subcutanous tissue
what are melanocytes
supply keratinocytes with melanosomes
what are the intercellular bridges between squamous cells
desmosomes
what makes up the papillary dermis
type I collagen, parallel to surface
some type III and network of elastic fiber
healing by secondary intention
capillaries of superficial plexus (blushing and sunburn)
what blistering immune diseases invade BM
bullous pemphigoid
dermatitis herpetiformis
epidermolysis bullosa
what is a pacinian corpuscle
encapsulated nerve ending
pressure R
found in deep dermis or hypodermis
what is a meissner corpuscle
touch R
confined to dermal papillae
most numerous on hands and feet
what type of nerves detect pain and temp
free nerve endings from sympathetic nervous system that controls blood flow and hair movement
what makes up the hypodermis
loose and dense CT
adipocytes arranged in lobules
fibroconnective tissue arranged in septae
pancreatitis has what type panniculitis
lobular
erythema nodosum has what type panniculitis
erythema nodosum
hypodermis connects what
reticular dermis with fascia of underlying tissue
roles of hypodermis (subcut)
body temp regulation (adipose)
primary depot for fat storage (large energy reserve)
aging most evident in this layer
what are wrinkles
basal layer proliferation decreased melanocytes
decrease langerhans
thinning of ground substance
what happens to hair follicles with age
decreased hair shaft diameter
decreased number hair follicles (decreased oil production leading to xerosis or dry skin)
what is solar elastosis
actinic degeneration of reticular dermis collagen
what is telangiectasia
small dilated blood vessels
what are the changes in dermis associated with sunburn
increased blood flow
superficial blood vessels show endothelial swelling, perivenular edema, mixed perivascular inflammatory infiltrate
