MSK path VIII Flashcards
Giant cell tumor
multinucleated osteoclast type giant cells “osteoclastoma”
benign, locally aggressive
20-40 y.o
where do giant cell tumors of bone grow
epiphyseal tumor
Cx in giant cell tumor
destroyed from buldging red brown mass with cystic degeneration
soap bubble tumor
giant cell tumor
Tx giant cell tumors
curettage
mets of giant cell tumors
lungs
what drug is effective in giant cell tumors
RANKL inhibitor denosumab
aneurysmal bone cyst
tumor characterized by multiloculated blood filled cystic spaces
where do primary anerysmal bone cysts occur
first 2 decades life in metaphysis of long bones
posterior elements of vertebral bodies
common signs and Sx aneurysmal bone cysts
pain and swelling
on radiograph see eccentric expansile lesion with well defined margins, msot lytic and have thin shell reactive bone at periphery
CT and MRI show internal septa and fluid fluid levels
aneurysmal bone cyst!!
describe cysts in ABC
blood filled spaces with tan white thin septae between
“blue bone” calcified matrix
aneurysmal bone cyst ABC
Tx ABC
surgical curettage or en bloc resection
fibrous cortical defects
metaphyseal fibrous defects
common in children >2 y.o
where do fibrous cortical defects arise
eccentrically metaphysis distal femur and proximal tibia
almost half b/l or multiple
