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Year2 MSK exam 1 > Derm path I > Flashcards

Derm path I Flashcards

1
Q

excoriation

A

traumatic lesion breaking epidermis causing scratch

self induced

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2
Q

lichenification

A

thick and rough skin

repeated rubbing causes it

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3
Q

what is a macule and patch

A

macule is 5 mm

circumscribed flat lesion distinguished from surrounding skin by color

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4
Q

what is a papule/ nodule

A

elevated dome shaped or flat topped lesion

papule 5mm

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5
Q

what is a plaque

A

elevated flat topped lesion

usually greater than 5 mm

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6
Q

what is a pustule

A

discrete pus filled raised lesion

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7
Q

what is a scale

A

dry horny platelike excrescence

usually from imperfect cornification

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8
Q

what is a blister
vesicle
bulla

A

any fluid filled raised lesion

vesicle 5mm

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9
Q

what is a wheal

A

itchy transient elevated lesion with variable blanching and erythema formed as result of dermal edema

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10
Q

acantholysis

A

loss of intercellular cohesion between keratinocytes

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11
Q

acanthosis

A

diffuse epidermal hyperplasia

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12
Q

dyskeratosis

A

abnormal premature keratinization within cells below the stratum granulosum

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13
Q

erosion

A

discontinuity of skin showing incomplete loss of epidermis

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14
Q

what is exocytosis

A

infiltration of the epidermis by inflammatory cells

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15
Q

hydropic swelling

A

intracellular edema of keratinocytes

often seen in viral infections

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16
Q

what is hypergranulosis

A

hyperplasia stratum grnaulosum from intesnse rubbing

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17
Q

what is hyperkeratosis

A

thickening of stratum corneum

assoc with qualitative abnormality of the keratin

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18
Q

lentiginous

A

linear pattern of melanocyte proliferation within epidermal basal cell layer

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19
Q

what is papillomatosis

A

surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae

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20
Q

parakeratosis

A

keratinization with retained nuclei in stratum corneum

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21
Q

spongiosis

A

intercellular edema of the epidermis

22
Q

ulceration

A

discontinuity of the skin whoing complete loss of epidermis revealing dermis or subcutis

23
Q

vacuoliation

A

formation of vacuoles within or adjacent to cells

refers to basal cell BM zone area

24
Q

what are fibroepithelial polyps

A

skin tags
acrochordon
fibroma molle
squamous papilloma

25
Q

fibroepithelial polyps are assoc with what

A

areas of rubbing by clothing (collar of neck or groin)

26
Q

other names for epithelial inclusion cyst

A

epithelial cyst
follicular cyst
wen

27
Q

where do epithelial inclusion cysts occur

A

face, scalp and upper trunk where there are lots of hair follicles

28
Q

cause of epithelial inclusion cysts

A

obstruction hair follicle above infundibulum near where hair shaft extends beyond skin surface

29
Q

micro epithelial inclusion cyst

A

filled with keratinous debris and lined by squamous epithelium with granular cell layer

30
Q

what occurs if epithelial inclusion cyst ruptures

A

provoke chronic inflammatory reaction with granuloma elicited by the extravasted keratin
(foreign body giant cell reaction

31
Q

cause of seborrheic keratosis

A

proliferation of epidermal basal cells

32
Q

where does seborrheic keratosis appear

A

non sun exposed skin like trunk and proximal extremities, lateral neck

33
Q

seborrheic keratosis can mimic what skin condition

A

malignant melanoma

34
Q

postage stamp appearance

A

seborrheic keratosis

35
Q

leser trelat

A

acute onset of seborrheic keratosis with malignancies (GI mostly)

36
Q

mutation in seborrheic keratosis

A

fibroblast growth factor R 3

37
Q

what is acanthosis nigricans

A

hyperpigmentation flexural regions: axilla, skin folds of neck, groin and anogenital regions

38
Q

acanthosis nigricans is hyperplasia of what

A

epidermal stratum spinosum

39
Q

acanthosis nigricans in childhood is most likely what

A

benign

40
Q

acanthosis nigricans acute onset in adult, need to look for what

A

underly malignant adenocarcinoma because these stimulate epidermis to undergo epidermal hyperplasia

41
Q

what do the benign adnexal neoplasms look like

A

symmetrical
small
superficial
vertical in orientation

42
Q

characteristics malignant adnexal tumors

A

asymmetrical large deep and wide

43
Q

what are the types of malignant adnexal tumors

A

sebaceous carcinoma
eccrine carcinoma
apocrine carcinoma

44
Q

most common type malignant adnexal tumor

A

sebaceous carcinoma

45
Q

trichoepithleiomas, trichofolliculoma, tricholemmoma and pilomatricoma all involve what

A

hair follicle

46
Q

what syndrome has multiple tricholemmomas with dominant inheritance

A

cowden syndrome

47
Q

sebaceous adenoma and sebaceous epithelioma involve what

A

sebaceous gland

48
Q

Muir Torre syndrome

A

sebaceous adenomas with association colorectal malignancy (lynch)

49
Q

syringoma, cylindroma, poroma involve what area of body

A

eccrine glands

50
Q

What is turban tumor

A

massive confluent cylindromas

51
Q

buds of basaloid cells that resemble primitive hair follicules

A

trichoepithelioma

Year2 MSK exam 1 (26 decks)

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