Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Year2 MSK exam 1 > MSK path X > Flashcards

MSK path X Flashcards

1
Q

What is enteritis assoc arthritis

A

GI infection causes it

yersinia salmonella shigella, campylobacter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

presentation enteritis assoc arthritis

A

knees and ankles
somtimes wrists fingers and toes
lasts for about a year then generally clears

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

kid has new murmur and puffy face

recently had infeciton, not compliant to antibiotics

A

post strep glomerulonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is Psoriatic arthritis

A

chronic inflammatory arthropathy assoc with psoriasis that affects peripheral and axial joints and entheses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are entheses

A

ligaments and tendons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Sx psoriatic arthritis

A 
30-50 years old
following onset of skin disease
peripheral joints of hands and feet
asymmetric distribution
"pencil in cup"
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

pencil in cup

A

psoriatic arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is atypical psoriatic lesion

A

not on elbow or knee at first presentation but on wrist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what infections are asplenic patients at risk for

A

H influenza
pneumococcal
because these are encapsulated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how do bacterial infections enter joints to cause infectious arthritis

A

hematogenous spread

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

presentation infectious arthritis

A

sudden acute paingul and swollen joint with dec ROM

fever, leukocytosis and increase sed rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

nongonococcal infecitous arthritis

A

single joint, usually knee

then hip shoulder elbow wrist and sternoclavicular joint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

axial joint involvement in infectious arthritis tells you what about patient

A

drug user

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Dx infectious arthritis

A

joint aspiration yielding purulent fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

lyme arthritis

A

caused by borrelia burgdorferi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what stage do lymes unTx patients develop arthritis and in what joints

A

late stage

knees, shoulders elbows ankles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

how long does lymes arthritis last

A

one or 2 joints for few weeks- months then moves to new sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Dx of lymes arthritis

A

anti-Borrelia Ab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Tx lymes arthritis

A

antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

early stage lymes presentation

A

erythema multiforme

targetoids

21
Q

what is crystal induced arthritis

A

acute and chronic joint disorders like gout and pseudogout

22
Q

what is psuedogout composed of

A

Ca pyrophosphate dehydrate

23
Q

what is gout made of

A

monoNa urate from broken down DNA

24
Q

majority gout

A

idiopathic

25
Q

secondary gout causes

A

increased nucleic acid turnover from leukemia
chronic renal disease
congenital

26
Q

what can cause primary gout

A

idiopathic and known enzyme defects like HGPRT

27
Q

what is hyperuricemia

A

plasma urate >6.8

28
Q

what can lead to hyperuricemia

A

increased production or decreased excretion

29
Q

inflammation in gout triggered by

A

precipitation of monoNa urate crystals into joints

recruits lymphocytes

30
Q

when does gout appear

A

after 20-30 years of hyperuricemia

31
Q

genetic predisposition to gout

A

male beause X linked abnormalities of HGPRT

32
Q

what polymorphisms can lead to gout

A

URAT1 and GLUT9

33
Q

what lifestyle factors contribute to gout

A

alcohol
obesity
drugs (thiazides)
lead toxicity

34
Q

what are the distinctive morphologic features of gout

A

acute arthritis
chronic tophaceous arthritis
tophi in various states
gouty nephropathy

35
Q

acute arthritis in gout

A

dense neutrophilic infiltrate

need shaped crystals

36
Q

chronic trophaceous arthritis in gout

A

repetitive precipitation of urate crystals during acute attacks
hyperplastic synovium with fibrosis and thickening by inflammatory cells and forms pannus that destroys cartilage

37
Q

what will gout look like grossly

A

white and chalky

38
Q

ASx hyperuricemia in males and females

A

males around puberty

females postmenopause

39
Q

locations for acture arthritic attacks from gout

A

insteps, ankles, heels, knees, wrists, fingers, elbows

40
Q

how long till get chronic trophaceous gout

A

12 years after initial attack

see juxtaarticular bone erosion from osteoclastic bone resorption and loss of joint space

41
Q

progression of chornic trophaceous gout can lead to

A

crippling disease

42
Q

pseudogout presentation

A

50+ years old

some swelling and redness, not as much

43
Q

crystal morph in pseudogout

A

oval blue purple aggregates
rhomboid crystals
inflammation

44
Q

how long does pseudogout last

A

several days to weeks

45
Q

where does pseudogout appear

A

monoarticular or poly

knees, wrists elbow, shoulders, ankles

46
Q

Tx for pseudogout

A

supportive

47
Q

if yellow crystals are parallel to axis then what

A

gout

48
Q

if yellow not parallel to axis then what

A

pseudogout

49
Q

what immune response is in RA

A

humoral and cellular

Year2 MSK exam 1 (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions