Derm path III Flashcards
ABCD melanoma
asymmetry
border irregularity
color variation
diameter
melanoma survival depends on what
stage
mets to lymph nodes
mortality of malignant melanoma is graded how
thickeness of melanoma
if melanoma is 4mm
92%
80%
50%
solar lentigo
focal autonomous overproduction of melanosomes with resultant sustained increase in melanin in kertinocytes
what is solar elastosis
permanent incremental damage to reticular collagen with loss of texture and wrinkling
what is actinic keratosis
neoplastic proliferation of keratinocytes that have no yet involved the full epidermal thickness
characterized by increased keratin production (scaling) and underlying dermal increase in vascularity (redness)
where does actinic keratosis occur
sun-exposed areas of scalp, face, dorsum forearms and hands
other names for actinic keratosis
solar keratosis
senile keratosis
keratinocytic intraepithelial neoplasia
appearance actinic keratosis
erythematous reddish brown macules or minimally elevated papules with overlying scales
size of lesions of actinic keratosis
mm to cm
SCC
malignant proliferation epidermal keratinocytes potential for mets to regional lymph nodes or distant sites
What is SCC in situ
bowden disease
most carcinogenic UV type
UV B wavelengths 280-340
other causes of sCC beside UV B
HPV
chornic ulcers and draining fistulous tracts
burns and radiation
chemical exposures
CA from chimeny sweeping tar
scrotal CA
what genetic syndromes increase chance SCC
epidermodysplasia verruciformis( predisposition to HPC infections and HPV subtypes 5 and 8) Xeroderma pigmentosa (nucleotide excision repair pathway defects)
second most common cutaneous malignancy in US
SCC
early apperance invasive SCC
small firm skin colored or erythematous nodule with indistince borders
what is surface of SCC
smooth, verrucous or papillomatous
appearance of older SCC
large, invasive and central area of tumor on skin can be ulcerated
keratoacanthoma
rapidly growing neoplasm on sun exposed areas of older adults
common outcome keratoacanthoma
spontaneously clears in 3-4 months
another term for keratoacanthoma
SCC keratoacanthoma type
basal cell carcinoma
several types of skin neoplasm originating from basal regenerative epithelium of erpidermis that almost never metastazies
types of BCC
nodular and sclerosins
etiology BCC
increased sunlight exposure in childhood and adolescence, chronic exposure during adulthood
What is Gorlin Syndrome
nevoid basal cell carcinoma syndrome
auto dominant
appearance of gorlin syndrome
multiple BCC before age 20 pits of palms and soles odontogenic keratocysts medulloblastomas ovarian fibromas
msot common cutaneous neoplasm
BCC
what is rodent ulcer
advanced presentation of basal cell carcinoma
nodular type BCC
traditional
dome shaped, pearly papule or nodule
prominent surface, dilated dermal vessels
what will histo of nodular BCC look like
isolated nests of basaloid cells within papillary dermis
nests separated from adjacent stroma by clefts (clear spaces)
rodent ulcer type BCC
sclerosing
yellowish white or pearly white
indurated plaque that may retract below plane of skin surface
poorly defined margins
difficult to excise, high recurrence rate
apperarance of superficial BCC
multifocal erythematous scaly plaque with rolled edenes
non sun exposed areas
dermal epidermal junction growth pattern
easily excised
what is dermatofibrosarcoma protuberans
malignant superficial fibroblastic neoplasm
locall aggressive, rarely mets
bednar tumor
pigmented variant dermatofibrosarcoma protuberans
mutation in dermatofibrosarcoma protuberans
translocation COL1A1 and PDGFB
“storiform” alignment of spindled cells
dermatofibrosarcoma protuberans
what type of neoplasm can mycosis fungoides cause
CD4 T cell lymphoma of skin
CLA CCR4 CCR10
prognosis mycosis fungoides
8-9 years
phases of mycosis fungoides
inflammatory erythrodermic pre-mycotic patch
plaque
tumor
what is sezary syndrome
variant in which skin involvement manifest as generalized exfoliative erythroderma
nuclei in sezary syndrome
cerebriform nuclei
what is mastocytosis
oivoid cells with centrally located nuclei
metachromatic granules in cytoplasm of mast cells
