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Year2 MSK exam 1 > Derm path III > Flashcards

Derm path III Flashcards

1
Q

ABCD melanoma

A

asymmetry
border irregularity
color variation
diameter

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2
Q

melanoma survival depends on what

A

stage

mets to lymph nodes

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3
Q

mortality of malignant melanoma is graded how

A

thickeness of melanoma

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4
Q

if melanoma is 4mm

A

92%
80%
50%

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5
Q

solar lentigo

A

focal autonomous overproduction of melanosomes with resultant sustained increase in melanin in kertinocytes

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6
Q

what is solar elastosis

A

permanent incremental damage to reticular collagen with loss of texture and wrinkling

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7
Q

what is actinic keratosis

A

neoplastic proliferation of keratinocytes that have no yet involved the full epidermal thickness
characterized by increased keratin production (scaling) and underlying dermal increase in vascularity (redness)

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8
Q

where does actinic keratosis occur

A

sun-exposed areas of scalp, face, dorsum forearms and hands

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9
Q

other names for actinic keratosis

A

solar keratosis
senile keratosis
keratinocytic intraepithelial neoplasia

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10
Q

appearance actinic keratosis

A

erythematous reddish brown macules or minimally elevated papules with overlying scales

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11
Q

size of lesions of actinic keratosis

A

mm to cm

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12
Q

SCC

A

malignant proliferation epidermal keratinocytes potential for mets to regional lymph nodes or distant sites

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13
Q

What is SCC in situ

A

bowden disease

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14
Q

most carcinogenic UV type

A

UV B wavelengths 280-340

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15
Q

other causes of sCC beside UV B

A

HPV
chornic ulcers and draining fistulous tracts
burns and radiation
chemical exposures

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16
Q

CA from chimeny sweeping tar

A

scrotal CA

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17
Q

what genetic syndromes increase chance SCC

A 
epidermodysplasia verruciformis( predisposition to HPC infections and HPV subtypes 5 and 8)
Xeroderma pigmentosa (nucleotide excision repair pathway defects)
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18
Q

second most common cutaneous malignancy in US

A

SCC

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19
Q

early apperance invasive SCC

A

small firm skin colored or erythematous nodule with indistince borders

20
Q

what is surface of SCC

A

smooth, verrucous or papillomatous

21
Q

appearance of older SCC

A

large, invasive and central area of tumor on skin can be ulcerated

22
Q

keratoacanthoma

A

rapidly growing neoplasm on sun exposed areas of older adults

23
Q

common outcome keratoacanthoma

A

spontaneously clears in 3-4 months

24
Q

another term for keratoacanthoma

A

SCC keratoacanthoma type

25
Q

basal cell carcinoma

A

several types of skin neoplasm originating from basal regenerative epithelium of erpidermis that almost never metastazies

26
Q

types of BCC

A

nodular and sclerosins

27
Q

etiology BCC

A

increased sunlight exposure in childhood and adolescence, chronic exposure during adulthood

28
Q

What is Gorlin Syndrome

A

nevoid basal cell carcinoma syndrome

auto dominant

29
Q

appearance of gorlin syndrome

A 
multiple BCC before age 20
pits of palms and soles
odontogenic keratocysts
medulloblastomas
ovarian fibromas
30
Q

msot common cutaneous neoplasm

A

BCC

31
Q

what is rodent ulcer

A

advanced presentation of basal cell carcinoma

32
Q

nodular type BCC

A

traditional
dome shaped, pearly papule or nodule
prominent surface, dilated dermal vessels

33
Q

what will histo of nodular BCC look like

A

isolated nests of basaloid cells within papillary dermis

nests separated from adjacent stroma by clefts (clear spaces)

34
Q

rodent ulcer type BCC

A

sclerosing
yellowish white or pearly white
indurated plaque that may retract below plane of skin surface
poorly defined margins
difficult to excise, high recurrence rate

35
Q

apperarance of superficial BCC

A

multifocal erythematous scaly plaque with rolled edenes
non sun exposed areas
dermal epidermal junction growth pattern
easily excised

36
Q

what is dermatofibrosarcoma protuberans

A

malignant superficial fibroblastic neoplasm

locall aggressive, rarely mets

37
Q

bednar tumor

A

pigmented variant dermatofibrosarcoma protuberans

38
Q

mutation in dermatofibrosarcoma protuberans

A

translocation COL1A1 and PDGFB

39
Q

“storiform” alignment of spindled cells

A

dermatofibrosarcoma protuberans

40
Q

what type of neoplasm can mycosis fungoides cause

A

CD4 T cell lymphoma of skin

CLA CCR4 CCR10

41
Q

prognosis mycosis fungoides

A

8-9 years

42
Q

phases of mycosis fungoides

A

inflammatory erythrodermic pre-mycotic patch
plaque
tumor

43
Q

what is sezary syndrome

A

variant in which skin involvement manifest as generalized exfoliative erythroderma

44
Q

nuclei in sezary syndrome

A

cerebriform nuclei

45
Q

what is mastocytosis

A

oivoid cells with centrally located nuclei

metachromatic granules in cytoplasm of mast cells

Year2 MSK exam 1 (26 decks)

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