Derm path III

Question 1

ABCD melanoma

Answer 1

asymmetry
border irregularity
color variation
diameter

Question 2

melanoma survival depends on what

Answer 2

stage

mets to lymph nodes

Question 3

mortality of malignant melanoma is graded how

Answer 3

thickeness of melanoma

Question 4

if melanoma is 4mm

Answer 4

92%
80%
50%

Question 5

solar lentigo

Answer 5

focal autonomous overproduction of melanosomes with resultant sustained increase in melanin in kertinocytes

Question 6

what is solar elastosis

Answer 6

permanent incremental damage to reticular collagen with loss of texture and wrinkling

Question 7

what is actinic keratosis

Answer 7

neoplastic proliferation of keratinocytes that have no yet involved the full epidermal thickness
characterized by increased keratin production (scaling) and underlying dermal increase in vascularity (redness)

Question 8

where does actinic keratosis occur

Answer 8

sun-exposed areas of scalp, face, dorsum forearms and hands

Question 9

other names for actinic keratosis

Answer 9

solar keratosis
senile keratosis
keratinocytic intraepithelial neoplasia

Question 10

appearance actinic keratosis

Answer 10

erythematous reddish brown macules or minimally elevated papules with overlying scales

Question 11

size of lesions of actinic keratosis

Answer 11

mm to cm

Question 12

SCC

Answer 12

malignant proliferation epidermal keratinocytes potential for mets to regional lymph nodes or distant sites

Question 13

What is SCC in situ

Answer 13

bowden disease

Question 14

most carcinogenic UV type

Answer 14

UV B wavelengths 280-340

Question 15

other causes of sCC beside UV B

Answer 15

HPV
chornic ulcers and draining fistulous tracts
burns and radiation
chemical exposures

Question 16

CA from chimeny sweeping tar

Answer 16

scrotal CA

Question 17

what genetic syndromes increase chance SCC

Answer 17

epidermodysplasia verruciformis( predisposition to HPC infections and HPV subtypes 5 and 8)
Xeroderma pigmentosa (nucleotide excision repair pathway defects)

Question 18

second most common cutaneous malignancy in US

Answer 18

SCC

Question 19

early apperance invasive SCC

Answer 19

small firm skin colored or erythematous nodule with indistince borders

Question 20

what is surface of SCC

Answer 20

smooth, verrucous or papillomatous

Question 21

appearance of older SCC

Answer 21

large, invasive and central area of tumor on skin can be ulcerated

Question 22

keratoacanthoma

Answer 22

rapidly growing neoplasm on sun exposed areas of older adults

Question 23

common outcome keratoacanthoma

Answer 23

spontaneously clears in 3-4 months

Question 24

another term for keratoacanthoma

Answer 24

SCC keratoacanthoma type

Question 25

basal cell carcinoma

Answer 25

several types of skin neoplasm originating from basal regenerative epithelium of erpidermis that almost never metastazies

Question 26

types of BCC

Answer 26

nodular and sclerosins

Question 27

etiology BCC

Answer 27

increased sunlight exposure in childhood and adolescence, chronic exposure during adulthood

Question 28

What is Gorlin Syndrome

Answer 28

nevoid basal cell carcinoma syndrome | auto dominant

Question 29

appearance of gorlin syndrome

Answer 29

``` multiple BCC before age 20 pits of palms and soles odontogenic keratocysts medulloblastomas ovarian fibromas ```

Question 30

msot common cutaneous neoplasm

Answer 30

BCC

Question 31

what is rodent ulcer

Answer 31

advanced presentation of basal cell carcinoma

Question 32

nodular type BCC

Answer 32

traditional dome shaped, pearly papule or nodule prominent surface, dilated dermal vessels

Question 33

what will histo of nodular BCC look like

Answer 33

isolated nests of basaloid cells within papillary dermis | nests separated from adjacent stroma by clefts (clear spaces)

Question 34

rodent ulcer type BCC

Answer 34

sclerosing yellowish white or pearly white indurated plaque that may retract below plane of skin surface poorly defined margins difficult to excise, high recurrence rate

Question 35

apperarance of superficial BCC

Answer 35

multifocal erythematous scaly plaque with rolled edenes non sun exposed areas dermal epidermal junction growth pattern easily excised

Question 36

what is dermatofibrosarcoma protuberans

Answer 36

malignant superficial fibroblastic neoplasm | locall aggressive, rarely mets

Question 37

bednar tumor

Answer 37

pigmented variant dermatofibrosarcoma protuberans

Question 38

mutation in dermatofibrosarcoma protuberans

Answer 38

translocation COL1A1 and PDGFB

Question 39

"storiform" alignment of spindled cells

Answer 39

dermatofibrosarcoma protuberans

Question 40

what type of neoplasm can mycosis fungoides cause

Answer 40

CD4 T cell lymphoma of skin | CLA CCR4 CCR10

Question 41

prognosis mycosis fungoides

Answer 41

8-9 years

Question 42

phases of mycosis fungoides

Answer 42

inflammatory erythrodermic pre-mycotic patch plaque tumor

Question 43

what is sezary syndrome

Answer 43

variant in which skin involvement manifest as generalized exfoliative erythroderma

Question 44

nuclei in sezary syndrome

Answer 44

cerebriform nuclei

Question 45

what is mastocytosis

Answer 45

oivoid cells with centrally located nuclei | metachromatic granules in cytoplasm of mast cells