MS Flashcards
What sensory/ motor problems with somebody with MS have
Arms/ legs numbness and tingling
Electric current sensation
Useless hand syndrome
What vision problems may somebody with MS have
Vision blurriness, loss of diplopia
5% of patients have the following symptoms at onset
- Bladder dysfunction
- Heat intolerance
- Dementia
- Movement disorder
- Pain
What symptoms are characteristic of demyelination
- Optic neuritis
- Lhermittes symptom
- Uhthoff phenomenon
- Useless hand
What is meant by a relapsing remitting pattern
Symptoms of MS get better and worse as if at random
What is meant by a primary progressive pattern
Symptoms get progressively worse
What is meant by a secondary progressive pattern
Symptoms begin off as relapsing remitting but then at one point begin to regularly get worse
What is MS
Inflammatory, demyelinating condition of the CNS, generally considered to be autoimmune
What is seen in brain imaging of MS
Lesions in time and space
Brain atrophy
What is required for diagnosis of MS
Neurologic deficits
Dissemination in space
Dissemination in time
Exclusion of other causes
How would a preactive lesion appear in MS
Activated microglia (brown) Loss of myelin
How would a chronic active MS lesion appear
Macrophages at lesion edge
Engulfed myelin in macrophages
How would a chronic inactive MS lesion appear
Demyelination
Repair/ remyelination
Axonal loss
Astrocyte scar
