Anatomy of physiology of pain Flashcards
3 types of pain
Nociceptive
Prolonged/ inflammatory
Neuropathic
Define nociceptive pain
Pain elicited by brief noxious stimulus
What is function of noxious pain
Prevent further damage
What is the result in a mutation of Nav1.7 channel
Presents with abnormal pain sensations
What is CIPA
Congenital insensitivity to pain with anhydrosis
What mutation causes CIPA
trkA
Receptor for nerve growth factor
What does trkA mutation lead to
Decreased pain sensitivity
Anhydrosis (inability to sweat)
Is prolonged/ inflammatory pain central or peripheral
Peripheral
What is prolonged/ inflammatory pain
Hypersensitivity from inflammation around an area of the body that has been injured
What is the biological function of inflammatory pain
Prevent further damage and assist tissue repair
Is chronic pain central or peripheral sensitisation
Central
Define chronic pain
Pain that has been present for 3 months that results from disease/ damage to PNS/CNS
What is neuropathic pain
Pain persists in the absence of initial injury
Several PNS and CNS abnormalities
What nerves sense pain from internal organs
General visceral afferents
What does pain from general visceral affarents respond to
Distention
Not sensitive to cutting or burning
Name the 4 stages of pain
Transduction
Transmission
Perception
Modulation
Describe phase 1 of pain
Transduction–> at the receptor
Noxious stimuli translated into electrical activity at sensory nerve endings
Describe phase 2 of pain
Transmission–> nerve fibres
Propagation of impulses along pain pathway
Describe phase 3 of pain
Perception–> areas of brain
Descrimination/ affect/ motivation
Describe phase 4 of pain
Modulation
Stages 1-3 are modified
What are nociceptors
Non-specialised receptors that use free nerve endings
Often polymodal
Define polymodal
Respond to more than one type of stimulus
Name 3 types of nociceptors
Cutaneous
Muscular
Visceral
Function of cutaneous nociceptors
Aid conversion of a noxious stimuli into an electrical impulse
What pain does TRPV1 receptor detect
heat and acid
What pain does ASIC receptor detect
Acid
What pain does TRPM8 receptor detect
Cold/ menthol
Define transmission
Travel of the receptor impulses along different pain pathways to different parts of the brain
Function of first order neurones
Carry sensory impulse from sensory receptor to CNS
What kind of pain is associated with a-delta fibres
Fast, prick pain
Function of a-delta fibres
Localising source of stimulus