MDS Flashcards

1
Q

Mimic of MDS boards likes to test

A

copper deficiency

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2
Q

Diseases associated with psuedo-pelger huet cells

A

CML, AML, MDS

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3
Q

Good risk cytogenetic findings in MDS

A

*-Y
- del5q
- del11q
- del12p
- del20q

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4
Q

Poor risk cytogenetic findings in MDS

A
  • complex karyotype
  • del7
  • inversions or deletions of chromosome 3
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5
Q

How to think of risk stratification of mutations in MDS

A
  • SF3b1 is good risk, everything else is bad risk
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6
Q

Treatment of choice for MDS w/ 5q-

A

lenalidomide

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7
Q

hypoplastic MDS managment

A

treated similar to aplastic anemia with triple IST

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8
Q

contraindication to use of iron chelators

A

CrCL<40

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9
Q

MDS bone marrow findings

A
  • hyperproliferative
  • cellular dysplasia
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10
Q

Demographics - gender + ethnicity at higher risk

A

Men at higher risk
White people at higher risk
*think MDS patient

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11
Q

Other MDS RF’s

A
  • radioactive iodine
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12
Q

hypoplastic MDS management

A

immunosuppression (treated similarly to aplastic anemia)
- cyclosporine + ATG

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13
Q

Mutation with most favorable prognosis in MDS

A

SF3B1

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14
Q

Disease associated with SRSF2

A

CMML

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