Essential thrombocythemia Flashcards
1
Q
Most common mutations in order
A
1) JAK2
2) MPL
3) CALR
2
Q
ET symptoms
A
- VTE
- headaches, dizziness, visual disturbances, burning dysesthesia of the palms and soles, numbness/tingling in extremities, cutaneous ulcers, cognitive or psychiatric deficits, or seizure-like activity.
3
Q
Bone marrow biopsy buzzwords for ET
A
- enlarged megakaryocytes with hyperlobulated nuclei
4
Q
Pregnant ET patient management
A
interferon alpha
5
Q
Low risk ET management
A
IF cardiovascular risk factors, aspirin 81 mg daily (to reduce incidence of vascular events and vasomotor symptoms)
*NO hydrea
