Coagulation

Question 1

What are the common pathway defects?

Answer 1

V, X (X marks the spot for PTT and PT and the V fits into the X)
II (prothrombin)
I (fibrinogen
*Just remember that these are the bills under 10

Question 2

Function of thrombin

Answer 2

Convert fibrinogen to fibrin

Question 3

Factor in PT pathway

Answer 3

7 (lucky number 7 activates factor X)

Question 4

Factors in PTT

Answer 4

8,9,11,
*12

Question 5

Pathognomic feature of acquired hemophilia on a mixing study

Answer 5

• after incubation, on second read out, re-prolongs (PTT is even longer) (autoantibodies take longer to inhibit)

Question 6

When is bethesda titer positive?

Answer 6

Any time you have an inhibitor
- congenital complicated by an inhibitor
- acquired hemophilia

Question 7

What conditions are associated with prolonged closure time with a PFA-100?2

Answer 7

1) platelet defects
2) VWF
*plt count <100 or hematocrit <30 will also lead to prolonged time

Question 8

Condition associated with FX deficiency

Answer 8

Amyloidosis (amyloid protein binds to it and removes it from circulation)

Question 9

DVT in obesity

Answer 9

BMI 40-50 - NOACs okay
BMI >50 - No NOAC, lovenox

Question 10

how do P2Y12 inhibitors work (clopidogel, prasugrel, ticagrelor, cangrelor)

Answer 10

Inhibit platelet surface receptor activation (block interaction with fibrinogen)

Question 11

What are the GPIIb/IIIa inhibitors?

Answer 11

abciximab
*tirofiban
*eptifibatide

Question 12

Aspirin mechanism

Answer 12

Irreversible COX inhibitor in platelets

Question 13

What are the GPIIb/IIIa inhibitors?

Answer 13

• abciximab
• tirofiban
• eptifibatide

Question 14

Difference between 3 factor and 4 factor PCC

Answer 14

The 3-factor-PCC contains factors II, IX, X, and little or no factor VII.