CAR-T Flashcards
1
Q
tisacel target
A
CD19
2
Q
liso-cel target
A
CD19
3
Q
axi-cel target
A
CD19
4
Q
brexi-cel target
A
CD19
5
Q
axi-cel and brexi-cel design that predisposes to higher risk of CRS
A
- CD28 costimulatory domain
6
Q
CAR-T SEs in general
A
*hypogammaglobulinemia
- CRS
- ICAHNS
*HLH
*b cell aplasia
*TLS
- neutropenic fever
7
Q
Primary physiologic mediator of CRS
A
IL-6 (think tocilizumab)
8
Q
CAR-T Se’s
A
- TLS
- CRS
- ICANSS
- b cell aplasia and hypogammaglobulinemia
9
Q
A
