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Heme boards > Last deck > Flashcards

Last deck Flashcards

1
Q

Preferred conditioning for CNS lymphoma

A

*Thiotepa based
TBC (thiotepa, busulfan, and cyclophosphamide) or TT-BCNU (thiotepa and carmustine)

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1
Q

Prophylaxis antepartum and postpartum for prothrombin gene mutation

A

Nothing

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2
Q

antepartum and postpartum prophylaxis for protein C and S deficiency

A

Only postpartum and only if family history of VTE

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3
Q

antepartum and postpartum prophylaxis for antithrombin deficiency

A
  • only if family history
    IF family history, then antepartum and postpartum
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4
Q

Least important HLA antigen

A

DQB1

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5
Q

Inv 16 associated gene

A

CBFB

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6
Q

Treatment of ciclic neutropenia

A

GCSF

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7
Q

Castleman’s disease second line

A

Rituximab

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8
Q

preferred management of unicentric castleman’s

A

Complete surgical resection

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9
Q

Rasburicase mechanism

A

Recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin.

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10
Q

Management of patient off TKI in CML with detectable BCR/ABL PCR

A

Repeat in 2 weeks, if still detectable, resume TKI

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11
Q

Universal blood donor type

A

O negative

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12
Q

HELLP mgmt

A
  • control BP
  • magnesium
    *noo role for steroids or PLEX
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13
Q

VWF and pregnancy goals

A
  • Levels of VWF and factor VIII be maintained at ≥50 IU/dL during delivery and for at least three to five days after delivery
  • Aim for VWF and Factor VIII close to 80-100% at time of delivery
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14
Q

RF’s for CNS involvement in ALL

A

??

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15
Q

Initial management of acquired PRCA

A
  • transfuse as needed
  • treat underlying illness
  • discontinue any implicated drugs
16
Q

Management of PRCA that doesn’t improve with initial measures

A
  • Cyclosporine
  • steroids
    IF parvovirus associated, IVIG
17
Q

Differentiation syndrome context + presentation

A
  • Typically in APML
  • fever + weight gain + hypotension + pulmonary infiltrates
18
Q

CAR-T approved for ALL

A
  • brexi-cell
  • tisa-cel
19
Q

Gene mutation associated with congenital AML?

A

KMT2A

20
Q

Definitive proof of transfusion associated GVHD

A

White blood cell chimerism (Different HLA phenotype in circulating lymphocytes compared with the HLA phenotype of host tissue cells)

Heme boards (59 decks)

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