Bleeding disorders Flashcards
Typical clinical presentation of acquired Factor VIII inhibitor
Old person w/ Spontaneous mucocutaneous bleeding
Factor XIII deficiency labs
Normal coags
Factor XI deficiency 1) clinical features 2) ethnic group
1) NO spontaneous bleeding, hemarthrosis, or muslce hematomas
BLeeding typically in setting of trauma or surgery - “injury-related bleeding disorder”
2) Jewish
Other name for factor XI deficiency
Hemophilia C
Correlation between Factor XI activity and bleeding manifestations
very poor
Treatment of bleeding in Factor XI pts
Minor bleeding:
Antifibrinolytics (mainstay)
Severe bleeding:
rFVIIa
*Factor XI concentrate not available in US
Factor VII deficiency inheritance pattern
- autosomal recessive
Factor VII clinical feature to remember
thrombotic tendency
Factor X deficiency inheritance
autosomal recessive
Correlation of Factor level with bleeding phenotype in Factor X
very good
Clinical conditions associated with factor X
Plasma cell dyscrasias
Factor X deficiency treatment
FX concentrate
IF not available, PCC vs. FFP
Treatment of plasma cell dyscrasia
Condition associated with Factor V deficiency
Quebec platelet disorder
Factor V deficiency treatment
1) FFP
2) Platelet transfusions (platelets have Factor V in alpha granules)
Factor V association
Topical Bovine thrombin
Factor XIII deficiency coags
normal
Factor XIII deficiency management
Recombinant FXIII A subunit product
IF not available, FFP or cryo
IF <10%, FXIII prophylaxis monthly due to ICH risk
Factor XIII deficiency clinical features
Delayed bleeding + ***umbilical stump bleeding as neonates + **Intracerebral hemorrhage + pregnancy loss
Pts at risk of developing prothrombin deficiency
APLS pts (
Treatment of acquired prothrombin deficiency (factor II deficiency)
Prothrombin complex concentrates (PCCs)
What is FEIBA?
activated prothrombin complex concentrate
What is Factor I
fibrinogen
Classical clinical vignette for fibrogen deficiency
Umbilical stump bleeding as a neonate
Clinical feature of dysfibrinogenema (qualitiative) to remember
Prothrombotic
