ASH SAP Flashcards
Preferred first line for primary CNS lymphoma
MATrix (Preferred – MTX + thiotepa + rituxan
Virus associated with PTLD
EBV
IHC specific finding of activated b cell subtype
MUM1
First line for anaplastic large t cell lymphoma
Brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (A-CHP) (ECHELON-2)
ALCL stands for
anaplastic large cell lymphoma
Favorable prognostic marker in ALCL
DUSP22 rearrangement
First line therapy for ALCL + components
Brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (A-CHP) (ECHELON-2)
ALCL consolidation
Transplant
Clinical presentation of angioimmunoblastic lymphoma
hemolytic anemia
AITL phenotype
CD4+, CD8-, expanded CD21+ follicular dendritic cell network, CD10, and PDL1+
Initial management of MCL
- depends on whether indolent disease or aggressive
- IF indolent, observation if no indications for treatment
- IF aggressive, BR preferred at UMASS (CONFIRM)
Bexarotene for CTCL AE’s
- hypertriglyceridemia
- central hypothyroidism
characteristic gene mutation in hairy cell
BRAF V600E
Translocation associated with reduced responsiveness to h pylori treatment in MALT lymphoma
t(11;18)
Marginal zone lymphoma immunophenotype
CD10-
What degree of tumor burden indicates treatment in FL
High tumor burden defined as:
Tumor >7 cm
3 nodes in 3 distinct areas, each > 3 cm in diameter
Symptomatic splenomegaly
Ascites or pleural effusion
t(14;18) chromosomal translocation in FL pairs BCL2 with which gene?
IGH
Translocation associated with favorable response in anaplastic large cell lymphoma
t(2;5)
Clinical features of primary effusion lymphoma (PEL)
1) neoplastic effusion
2),typically in setting of immunosuppression (post transplant or HIV)
3) no significant adenopathy or tumor masses
Viruses associated with PEL
HHV8 (kaposi sarcoma-associated herpesvirus)
Gene mutation associated with ALCL
ALK, the Anaplastic Lymphoma Kinase gene
Gene associated with primary cutaneous ALCL
MUM1/IRF4 gene.
