ITP Flashcards

1
Q

Target of antibodies on platelet surface in ITP

A

-platelet membrane glycoproteins IIb-IIIa or Ib-IX
- immunoglobulin G (IgG) type.

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2
Q

causes of ITP

A
  • idiopathic most commonly
  • viruses
  • vaccinations
  • medications
  • CLL
  • VWF type 2B
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3
Q

Von willebrand subtype that can cause ITP

A

2B

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4
Q

Gender predominance of ITP

A

Females (3:1, autoimmune…)

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5
Q

fostamatinib mechanism

A

SYK inhibition

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6
Q

Other SE’s of IVIG

A

Headache
Aseptic meningitis
Thrombosis
*FDA black box warning for renal failure

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7
Q

Rituxan SE’s

A
  • serum sickness
  • infusion reactions
  • infection
  • persistent hypogammaglobulinemia
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8
Q

First line therapy for ITP in pregnancy

A

steroids +/- IVIG

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9
Q

Eltrombopag SE’s to know

A
  • hepatotoxicity
  • VTE
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10
Q

Refractory ITP in pregnancy mgmt options

A
  • anti-D immunoglobulin
  • azathioprine
  • splenectomy can be done
    *TPO agonist safety data is limited but emerging information suggests they are safe
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11
Q

Neonatal alloimmune thrombocytopenia management

A
  • transfuse HPA-1a antigen negative platelets
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12
Q

ITP smear

A

Large platelets

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13
Q

MEchanism of steroids in ITP

A
  • decreased phagocytosis of antibody-coated platelet by phagocytes in both the spleen and liver
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14
Q

Mechanism of IVIG in ITP

A

Fc receptor blockade

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15
Q

Sequela of splenectomy for ITP

A

*VTE
Increased infection risk

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