ITP Flashcards
Target of antibodies on platelet surface in ITP
-platelet membrane glycoproteins IIb-IIIa or Ib-IX
- immunoglobulin G (IgG) type.
causes of ITP
- idiopathic most commonly
- viruses
- vaccinations
- medications
- CLL
- VWF type 2B
Von willebrand subtype that can cause ITP
2B
Gender predominance of ITP
Females (3:1, autoimmune…)
fostamatinib mechanism
SYK inhibition
Other SE’s of IVIG
Headache
Aseptic meningitis
Thrombosis
*FDA black box warning for renal failure
Rituxan SE’s
- serum sickness
- infusion reactions
- infection
- persistent hypogammaglobulinemia
First line therapy for ITP in pregnancy
steroids +/- IVIG
Eltrombopag SE’s to know
- hepatotoxicity
- VTE
Refractory ITP in pregnancy mgmt options
- anti-D immunoglobulin
- azathioprine
- splenectomy can be done
*TPO agonist safety data is limited but emerging information suggests they are safe
Neonatal alloimmune thrombocytopenia management
- transfuse HPA-1a antigen negative platelets
ITP smear
Large platelets
MEchanism of steroids in ITP
- decreased phagocytosis of antibody-coated platelet by phagocytes in both the spleen and liver
Mechanism of IVIG in ITP
Fc receptor blockade
Sequela of splenectomy for ITP
*VTE
Increased infection risk