ITP Flashcards
1
Q
Target of antibodies on platelet surface in ITP
A
-platelet membrane glycoproteins IIb-IIIa or Ib-IX
- immunoglobulin G (IgG) type.
2
Q
causes of ITP
A
- idiopathic most commonly
- viruses
- vaccinations
- medications
- CLL
- VWF type 2B
3
Q
Von willebrand subtype that can cause ITP
A
2B
4
Q
Gender predominance of ITP
A
Females (3:1, autoimmune…)
5
Q
fostamatinib mechanism
A
SYK inhibition
6
Q
Other SE’s of IVIG
A
Headache
Aseptic meningitis
Thrombosis
*FDA black box warning for renal failure
7
Q
Rituxan SE’s
A
- serum sickness
- infusion reactions
- infection
- persistent hypogammaglobulinemia
8
Q
First line therapy for ITP in pregnancy
A
steroids +/- IVIG
9
Q
Eltrombopag SE’s to know
A
- hepatotoxicity
- VTE
10
Q
Refractory ITP in pregnancy mgmt options
A
- anti-D immunoglobulin
- azathioprine
- splenectomy can be done
*TPO agonist safety data is limited but emerging information suggests they are safe
11
Q
Neonatal alloimmune thrombocytopenia management
A
- transfuse HPA-1a antigen negative platelets
12
Q
ITP smear
A
Large platelets
13
Q
MEchanism of steroids in ITP
A
- decreased phagocytosis of antibody-coated platelet by phagocytes in both the spleen and liver
14
Q
Mechanism of IVIG in ITP
A
Fc receptor blockade
15
Q
Sequela of splenectomy for ITP
A
*VTE
Increased infection risk
