MAGNESIUM SULFATE (MgS04)

Question 1

CLASS (3)

Answer 1

ELECTROLYTE

CNS DEPRESSANT

ANTICONVULSANT

Question 2

ACTIONS (3)

Answer 2

FOR TREATMENT OR PROPHYLAXIS OF SEIZURES DUTE TO TOXEMIA OF PREGNANCY BY DECREASING NEURONAL EXCITIBILITY (ANTICONVULSANT)

REDUCES THE INCIDENCE OF POSTINFARCTION VENTRICULAR ARRHYTHMIAS BY INCREASING MEMBRANE STABILITY AND DECREASING VENTRICULAR EXCITABILITY

MAY RESULT IN RELAXATION OF BRONCHIAL AND VASCULAR SMOOTH MUSCLE WHICH IS PROBABLY SECONDARY TO CALCIUM BLOCKADE

Question 3

INDICATIONS (7)

Answer 3

REFRACTORY VF / VT

TORSADES DE POINTES

REFRACTORY SEIZURES RELATED TO HYPOMAGNESEMIA ESPECIALLY IN ALCOHOLICS

ECLAMPSIA

HYPER REFLEXIA OF TOXEMIA OF PREGNANCY (PRE-ECLAMPSIA

CARDIAC ARRHYTHMIAS DUE TO DIG TOXICITY

CONTROVERSIAL: REFRACTORY BRONCHOSPASM NOT RESPONSIVE TO BETA AGONIST, STEROIDS, AMINOPHYILINE

Question 4

DOSAGE / ROUTE (4)

Answer 4

FOR ACUTE ADMINISTRATION DURING VT, 1 OR 2 G OF MAGNESIUM SULFATE IN 10 CC OVER 1-2 MINUTES

IN VF SHOULD BE GIVEN IV PUSH, FOLLOW UP INFUSION OF 0,5 - 1.0 G/HR FOR 24 HR

TORSADES = 2.0 G IV BOLUS, FOLLOWED BY 2nd 2.0 G BOLUS, IF NO RESPONSE FOLLOWED BY INFUSION

ANTICONVULSANT = 1-4G IV OVER 30 MINUTES OR MORE RAPIDLY SEIZING FOR OVER 5MIN.

Question 5

STANDARD PREP

Answer 5

1 GM/2 ML, 5 GM/10 ML

Question 6

CONTRAINDICATIONS

Answer 6

HEART BLOCK, CONTROVERSY IN ACUTE MI PATIENT

Question 7

SIDE EFFECTS

Answer 7

FROM TOO RAPID IV ADMINISTRATION: FLUSHING, HYPOTENSION, SWEATING, MILD BRADYCARDIA

HYPERMAGNESEMIA MAY PRODUCE DEPRESSED REFLEXES (PATELLA), FLACCID PARALYSIS, CIRCULATORY COLLAPSE, RESPIRATORY DEPRESSION OR PARALYSIS, AND DIARRHEA

Question 8

PRECAUTIONS (5)

Answer 8

MONITORY RR BECAUSE OF RESPIRATORY DEPRESSION

IV CALCIUM CHLORIDE SHOULD BE AVAILABLE AS AN ANTAGONIST

CONCURRENT USE WITH CNS DEPRESSANT REQUIRES LOWER DOSAGE ADJUSTMENTS

MONITOR EKG

USE WITH CAUTION IN RENAL FAILURE PATIENTS.