ALTEPLASE (T-PA, ACTIVASE)

Question 1

CLASS

Answer 1

FIBRINOLYTIC AGENT

Question 2

ACTIONS (2)

Answer 2

BINDS TO FIBRIN IN A CLOT OCCLUDING A CORONARY ARTERY

CONVERTS PLASMINOGEN TO PLASMIN. PLASMIN INITIATES THE FIBRINOLYTIC PATHWAY TO DISSOLVE THE CLOT. t-PA THEORETICALLY EXERTS A MORE LOCALIZED EFFECT THAN STREPTOKINASE.

Question 3

INDICATION

Answer 3

AMI MEETING CRITERIA OF ESTABLISHED PROTOCOL

Question 4

CONTRAINDICATIONS (6)

Answer 4

RECENT SURGERY

RECENT CVA, HEAD TRAUMA

BLEEDING DISORDER, RECENT TRAUMA

SEVERE UNCONTROLLED HTN

ANEURYSM

SEE MEDICATION LIST FOR A MORE THOROUGH LIST

Question 5

SIDE EFFECTS (4)

Answer 5

REPERFUSION ARRHYTHMIAS

CVA

BLEEDING DISORDER

REOCCLUSION