Lecture 9 Flashcards
1
Q
what are the types of tyrosine kinase receptors
A
-TrkA,B or C
2
Q
what are examples of neurotrophic factors
A
NGF, BDNF, NTF3, NTF4/5
3
Q
the influence of growth and trophic factors depends now what
A
- subtype of Trk receptors
- locations of target neurons
- downstream effect of the signaling cascade
4
Q
where are truncated TRK located and what do they do
A
located on neuroglia to maintain homeostasis
5
Q
what is the TRK pathway
A
- ligand binds causing dimerization
- RTK phosphorylates itself
- GRB2 (an SH2 containing protein) recognizes the phosphotyrosine resides
- binding of GRB2 recruits SOS
- SOS activates Ras by swapping GTP for GDP
- activated GTP-Ras recruits Raf-1 and activates it
- raf-1 phosphorylates and activates MEK
- MEK phosphorylates MAPK
- MAPK phosphorylates cellular proteins
- MAPK goes to nucleus and phosphorylates a transcription factor
6
Q
what are the classes of catalytic receptors
A
- receptor guanylyl cyclase
- receptor serine/threonine kinase
- receptor tyrosine kinase
- tyrosine kinase associated receptors
- receptor tyrosine phosphatases
7
Q
what is an example of a receptor guanylyl cyclase
A
ANP receptor
8
Q
what is an example of a receptor serine/threonine kinase
A
TGF- beta receptor
9
Q
what is an example of a receptor tyrosine kinase
A
NGF receptor, insulin receptor
10
Q
what is an example of a tyrosine kinase associated receptor
A
growth hormone receptor
11
Q
what is an example of a receptor tyrosine phosphatase
A
CD45
