Lecture 4 Block 3 Flashcards
what NT do glutamate neurons release
glutamate
what NT do GABA neurons release
BABA
what are ionotropic glutamates receptors permeable to
Na+ and K+
what type of response do inotropic glutamate receptors elicit
excitatory/ EPSP
what are inotropic GABA receptors permeable to
Cl-
what type of response to inotropic GABA receptors elicit
inhibitory/ IPSP
what are the types of glutamate receptors
NMDA and AMPA
what do AMPA receptors do
depolarize postsynaptic neurons
what do NMDA receptors require for activation
glutamate binding and depolarization
what are NMDA receptor channels permeable to
Ca2+
what is the LTP mechanism
- activity in presynaptic neuron activate postsynaptic AMPA receptors
- activated AMPA receptors depolarize postsynaptic neuron
- Mg2+ blockade of NMDA receptor is removed and NMDA receptor is activated by glutamate
- Ca2+ entry through NMDA receptor channel
- activation of CamKII leads to insertion of AMPA receptors in postsynaptic membrane of AMPA receptor phosphorylation
- retrograde messenger increases presynaptic transmitter release
how can a synapse be weakened
repeated stimulation of a synapse at a low frequency results in weakening of synapse (LTD)
what does presynaptic activity and postsynaptic depolarization trigger
calcium entry through NMDA receptor and LTP
what are mechanisms underlying learning and memory
homosynaptic and associative LTP and homosynaptic LTD
what is homosynaptic LTP
LTP induced by one large synapse
