Lecture 10 Flashcards
what neurotransmitter is used to activate fiber contraction
acetylcholine
where are ACH receptors anchored
at post synaptic cell of NMJ
what happens to ACH receptors when a motor neuron approaches
they aggregate to one area of the newly forming NMJ
what are the possible results of the NT binding in synaptic transmission
either converts signal back to electrical signal to finish its communication pathway or results in activating cell signaling pathways affecting function in post synaptic cell
what are the 2 classes of NTs
- large peptide
- small amines and amino acids
what is an example of a large peptide and a small amine
large peptide- substance P , enkephalin
small amine- acetylcholine, glycine
where does synthesis occur in large peptides and small amines
large peptides- cell body
small amine- terminal bouton
where does trafficking occur in large peptides and small amines
large peptides- large vesicles, axonal transport
small amines- small vesicles
how are vesicles recycled in large peptides and small amines
large peptides- vesicle component back to cell body for reuse
small amines- vesicles and substrates recycled at bouton
what are the post synaptic effects of large peptides and small amines
large peptides- metabotropic
small amines- can either be inotropic or local metabotropic
what are two structural ways the NMJ ensures depolarization
- presynaptic structure fits snugly into post synaptic cleft so ACh will stay close
- the active zones have matched lines of vesicles with Its of pre synaptic cleft to lines of their receptors on the post synaptic cleft
what do SNARE proteins do
pull vesicles down to the presynaptic membrane enabling fusion and release of NT into synaptic cleft
what kind of SNARE protein is SNAP25
target
what kind of SNARE protein in syntaxin
target
what kind of SNARE protein is synaptobrevin
vesicle
