Lecture 17 Flashcards

1
Q

What are the 2 parts of the pancreas

A

Exocrine

  • Acini: secrete digestive enzymes and bicarbonate

Endocrine

  • Islets of langerhans: secrete hormones
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2
Q
A

Pancian Corpiscles

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3
Q

Incidental findings or pancreas

A
  1. Ectopic pancreatic tissue
  2. Pacinian corpsuscles
  3. Pancreatic calculi
  4. Stromal fat infiltration
  5. Autolysis is very rapid after death
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4
Q

What is the problem with failure of pancreas to secrete digestive enzymes

A
  1. Inadequate pancreatic secretions cause incomplete digestion
  2. Maldigestion and secondary melabsorption - weight loss
  3. Build up of undigestied nutrients - malabsorption
  4. Small intestinal bacterial overgrowth
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5
Q

Causese of exocrine pancreatic insufficiency

A

Exocrine pancreatic atrophy

Chronic, recurrent pancreatitis -> most common in cats

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6
Q

What does exocrine pancreatic atrophy results from

A

Dramatically reduced pancreatic mass

  • Somethhing in immune system is causing atrophy

Most common in shepards and collies

Usually in young animals

Signs of maldigestion

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7
Q
A

Pancreatic atrophy - low enzyme levels

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8
Q

Mechanisms of pancreatitis include

A
  1. Obstruction of pancreatic ducts
  2. Direct injury to aciner cells
  3. Disturbed enzyme flow in acinear cells
  4. High fat meals
  5. Idiopathic
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9
Q

Where do you see acute pancreatitis

A

Dogs, esp obese, sedentary bitches

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10
Q

What happens woth acute pancreatitis

A

Necrosis and inflammation

Leakage/release of activates pancreatic enzymes

  • trypin

Autodigestion

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11
Q

What is the gross pathology of acute pancreatitis

A
  1. Degeneration/necrosis
  2. Degeneration of BV
  3. Fat necrosis
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12
Q

What is the histopathology pathology of acute pancreatitis

A
  1. Extensive haemorrhage
  2. Necrosis of pancreatic parenchyma
  3. Inflammatory cell infiltration
  4. Fibrinous exudate in septa
  5. Fat necrosis
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13
Q
A
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14
Q
A

Acute pancreatitis

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15
Q
A

Acute pancreatitis

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16
Q
A

Pancreatitis with enzymatic fat necrosis

17
Q

Effects of acute pancreatitis

A

Fatal when severe

  • Wide spread vascular damage
  • Shock
  • DIC
  • Sudden death
19
Q

What are the two syndromes of pancreatitis in cats

A
  1. Acute pancreatic necrosis
  2. Suppurative pancreatitis
20
Q

When do you see acute pancreatsis in horses

A

Migration of strongyle larvae

21
Q

What causes chronic pancreatitis

A

Where the liver cant regnerate

22
Q

What deos chronic pancreatitis cause

A
  1. Fibrosis
  2. Atrophy
  3. Lymphoplasmacytic infiltration
23
Q

Gross pathology of chronic pancreatitis

A
  1. Shrunken and nodular
  2. Fibrous adhesions to adjacent tissue
24
Q

Histopathology of chronic pancreatitis

A
  1. Fibrosis and atrophy
  2. Lymphoplasmacytic infltration
25
Chronic Recurrent Pancreatitis
26
Chrinic pancreatitis
27
28
Chronic pancreatitis
29
Where do you see pancreatic nodulat hyperplasoa
Old dogs and cats and also cattle
30
What is pancreatic adenoma
Single large nodules
31
What is pancreatic carcinoma
Single or multiple grey/yellow nodules - invasive, may contain necrosis, adhesion
32
What are pancreatic nodular hyperplasia
Multiple raised smooth nodules
33
Pancreatic nodular exocrine hyperplasia
34
Pancreatic nodular exocrine hyperplasia
35
36
Pancreatic adenocarcinoma
37
Pancreatic adenocarcinoma
38
Cats develop a unique cutaneous paraneoplastic syndrome Symmetric alopecia of the ventral trunk ans limbs with a glistening appearance