Lecture 17

Question 1

What are the 2 parts of the pancreas

Answer 1

Exocrine

• Acini: secrete digestive enzymes and bicarbonate

Endocrine

• Islets of langerhans: secrete hormones

Question 2

Answer 2

Pancian Corpiscles

Question 3

Incidental findings or pancreas

Answer 3

1. Ectopic pancreatic tissue
2. Pacinian corpsuscles
3. Pancreatic calculi
4. Stromal fat infiltration
5. Autolysis is very rapid after death

Question 4

What is the problem with failure of pancreas to secrete digestive enzymes

Answer 4

1. Inadequate pancreatic secretions cause incomplete digestion
2. Maldigestion and secondary melabsorption - weight loss
3. Build up of undigestied nutrients - malabsorption
4. Small intestinal bacterial overgrowth

Question 5

Causese of exocrine pancreatic insufficiency

Answer 5

Exocrine pancreatic atrophy

Chronic, recurrent pancreatitis -> most common in cats

Question 6

What does exocrine pancreatic atrophy results from

Answer 6

Dramatically reduced pancreatic mass

• Somethhing in immune system is causing atrophy

Most common in shepards and collies

Usually in young animals

Signs of maldigestion

Question 7

Answer 7

Pancreatic atrophy - low enzyme levels

Question 8

Mechanisms of pancreatitis include

Answer 8

1. Obstruction of pancreatic ducts
2. Direct injury to aciner cells
3. Disturbed enzyme flow in acinear cells
4. High fat meals
5. Idiopathic

Question 9

Where do you see acute pancreatitis

Answer 9

Dogs, esp obese, sedentary bitches

Question 10

What happens woth acute pancreatitis

Answer 10

Necrosis and inflammation

Leakage/release of activates pancreatic enzymes

• trypin

Autodigestion

Question 11

What is the gross pathology of acute pancreatitis

Answer 11

1. Degeneration/necrosis
2. Degeneration of BV
3. Fat necrosis

Question 12

What is the histopathology pathology of acute pancreatitis

Answer 12

1. Extensive haemorrhage
2. Necrosis of pancreatic parenchyma
3. Inflammatory cell infiltration
4. Fibrinous exudate in septa
5. Fat necrosis

Question 14

Answer 14

Acute pancreatitis

Question 15

Answer 15

Acute pancreatitis

Question 16

Answer 16

Pancreatitis with enzymatic fat necrosis

Question 17

Effects of acute pancreatitis

Answer 17

Fatal when severe

• Wide spread vascular damage
• Shock
• DIC
• Sudden death

Question 19

What are the two syndromes of pancreatitis in cats

Answer 19

1. Acute pancreatic necrosis
2. Suppurative pancreatitis

Question 20

When do you see acute pancreatsis in horses

Answer 20

Migration of strongyle larvae

Question 21

What causes chronic pancreatitis

Answer 21

Where the liver cant regnerate

Question 22

What deos chronic pancreatitis cause

Answer 22

1. Fibrosis
2. Atrophy
3. Lymphoplasmacytic infiltration

Question 23

Gross pathology of chronic pancreatitis

Answer 23

1. Shrunken and nodular
2. Fibrous adhesions to adjacent tissue

Question 24

Histopathology of chronic pancreatitis

Answer 24

1. Fibrosis and atrophy
2. Lymphoplasmacytic infltration

Question 25

Answer 25

Chronic Recurrent Pancreatitis

Question 26

Answer 26

Chrinic pancreatitis

Question 28

Answer 28

Chronic pancreatitis

Question 29

Where do you see pancreatic nodulat hyperplasoa

Answer 29

Old dogs and cats and also cattle

Question 30

What is pancreatic adenoma

Answer 30

Single large nodules

Question 31

What is pancreatic carcinoma

Answer 31

Single or multiple grey/yellow nodules - invasive, may contain necrosis, adhesion

Question 32

What are pancreatic nodular hyperplasia

Answer 32

Multiple raised smooth nodules

Answer 33

Pancreatic nodular exocrine hyperplasia

Question 34

Answer 34

Pancreatic nodular exocrine hyperplasia

Question 36

Answer 36

Pancreatic adenocarcinoma

Question 37

Answer 37

Pancreatic adenocarcinoma

Question 38

Answer 38

Cats develop a unique cutaneous paraneoplastic syndrome

Symmetric alopecia of the ventral trunk ans limbs with a glistening appearance