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Pathology > Lecture 16 > Flashcards

Lecture 16 Flashcards

1
Q

What is hepatic lipidosis

A

Excess lipid accumulation on the liver - When rate of triglyceride accumulation in hepatocytes exceeds rate of degradation or secretion as lipoprotein

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2
Q

What are the gross features of hepatic lipidosis/steatosis/fatty liver

A

The liver is diffusely enlarged, diffusely pale, greasy, friable and may float in water or fixative

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3
Q

What are the histological features of hepatic lipidosis/steatosis/fatty liver

A

Hepatocytes are enlarged with vacuolated cytoplasm. Vacuoles are round and sharply delineated. The vacuoles may be large and single or small and multiple. The nucleus is often displaced peripherally

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4
Q

What animals get ketosis

A

Animals with very high energy demands In times of energy demand: FFAs released from adipose Oxidised to ketones in liver When fat metabolism becomes excessive - Ketones in blood and urine - Hypoglycaemia - Low glycogen in liver

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5
Q

Where is glycogen accumulation seen

A

In liver

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6
Q

What is systemic amyloidosis

A

Deposition of proteins composed of B-pleased sheets in liver, kidney, spleen, brain

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7
Q

What are the two main forms of systemic amyloidosis

A

Primary: AK from plasma cell neoplasms Secondary: AA from liver

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8
Q

What stain to use to see amyloidosis

A

Congo red stain or polarised light to differentiate amyloid from other eosinophilic proteinaceous deposits

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9
Q

How do animals get chronic copper tocicosis

A
  • Dietary excess in ruminants - Deficient molybdenum in pasture - Pasture with hepatotoxins - Occ. hereditary or familial in dogs
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10
Q

How does copper accumulate in the liver

A

It’s progressive over time Stressful event can trigger copper release

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11
Q

Bile pigments in liver

A

Bilirubin: greenish liver, jaundice in other tissues

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12
Q

Haemosiderin in liver

A

Golden brown iron pigment from RBC breakdown

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13
Q

Lipofuscin in liver

A

Golden brown pigment ass. with ageing

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14
Q

Melanin in liver

A

Black or dark brown innocuous endogenous pigment

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15
Q

Parasite haematin in liver

A

Very dark excreta from liver flukes

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16
Q

What causes bilirubin

A

Breakdown of RBC

17
Q

What is the cause of hyperbilirubinaemia

A

Imbalance between production and excretion of bilirubin - Excess production - haemolysis of RBCs - Liver damage - reduced uptake or conjugation - Cholestasis - reduced outflow of bile due to obstruction

18
Q

What is haemosiderin

A

Ferritin and protein complex from break down or RBCs and appears golden brown granules

19
Q

What do you stain haemosiderin with

A

Blue with Perl’s Prussian Blue Stain

20
Q

What is hepatosis dietetica

A

Acute hepatic necrosis due to nutrition

21
Q

What is a nutritional liver disease

A

Ovine white liver disease - Pale, fatty livers in sheep - Caused by deficiency in cobalt - Soil depleted in cobalt

22
Q
A

Hepatic Lipidosis/ Steatosis/ Fatty liver

23
Q
A

Cytology of fatty liver

24
Q
A

Histology of fatty liver

25
Q
A

Equine Hyperlipidaemia

26
Q
A

Glucocorticoid hepatopathy (glycogen accumulation)

27
Q
A

Glucocorticoid hepatopathy

28
Q
A

Amyloidosis

29
Q
A

Chronic copper accumulation in the liver: acutw ahemolysis

30
Q
A

Hepatic copper accumulation

31
Q
A

Bile Pigments

32
Q
A

Hyperbilirubinaemia

33
Q
A

Haemosiderin Accumulation

34
Q
A

Parasire haematin in liver: due to migrating fasciola

35
Q
A

Hepatosis Dietetica: vitamin E / selenium deficiency

36
Q
A

Hepatosis Dietetica: centrolobular necrosis

Pathology (26 decks)

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