L19: Respiratory Infections Flashcards
What sort of respiratory infections are there
Bronchitis Pneumonia TB Bronchiectasis Cystic fibrosis Acute exacerbation of COPD or asthma
What are the 2 types of bronchial infections
Acute bronchitis
Recurrent bronchitis
Who does acute bronchitis occur in
Previously well people
What are features of acute bronchitis
Cough and sputum
What is recurrent bronchitis
Cough and sputum over at least 2 months
What is chronic bronchitis
Flem for 3 months over 2 years
What are the underlying cause for recurrent bronchitis
Sinus infection
Past nasal drip
Bronchiectasis
What are the 2 types of pneumonia
Typical pneumonia
Atypical pneumonia
Who does typical pneumonia occur in
People with pre-existing lung disease
What are the sympmtoms of typical pneumonia
Pleuritic pain
Purple the pain
High temperature
Crackles and dullness and increased vocal resonance in the lungs
What is the treatment for typical pneumonia
Beta lactams (penicillins)
Who does atypical pneumonia occur in
Previously well people
What are the symptoms of atypical pneumonia
Dry cough
Wheeze
Does atypical pneumonia react to beta lactams (penicilin)
No
Is it hard to distinguish between typical and atypical pneumonia in patients
Yes
If distinguishing the 2 types of pneumonia is difficult how do we treat it
Use 2 different antibiotic at the same time two cover both bases of pneumonia
What are the pathogens that can cause pneumonia
Mycoplasma
Legionella
When does mycoplasma come in
Winter peaks and epidemics
What is legionella related to
Travel to Spain and turkey
Clusters
How do we diagnose pneumonia
Chest x-ray
What does pneumonia look like an a chest x-ray
Opacity (white over the lobe of infection)
Loss of right heart border (if middle lobe)
Loss of right diaphragm (if lower lobe)
What are the other features on a chest x-ray for pneumonia
Cavities
What are cavities
Areas of dark area
How do we manage pneumonia that is non severe
Amoxycilin and macrolide
What type of drug is amoxycilin
Beta lactam antibiotic
How do we manage severe cases of pnuemonia
Intra venous amoxiclav and IV macrolide
What are the complications of pnuemonia
Respiratory failure
Lung abscess
Parapneumonic effusion
What happens to the fluid in parapneumounic effusion as it goes from simple to complex to empyema
Thickens
What is the management of empyema
Antibiotics
Drainage
Surgery
What are the antibiotics used to manage empyema
Penicillins
Metronidazole
What is tuberculosis caused by
Mycobacteria TB
What are the symptoms of tuberculosis
Night sweats Fevers Weight loss Productive cough Haemoptysis
How do we diagnose TB
Test sputum Bronchoscopy if there is no sputum Test for HIV Aspirate lymph node Vitamin d levels (deficiency)
Where does TB spread in the body
Meninges (brain) Musculoskeletal Genitourinary Gastrointestinal Pericardial (lining of the heart)
What does the treatment of TB involve
4 different antibiotics
What are the 4 different antibiotics used to treat TB
Isoniazid
Pyrizinamide
Rifampicin
Ethambutol
What are the problems with treating TB
Resistance to TB bugs
Drug interactions and side effects
What is the most common side effect from antibiotics
Hepatitis
What is hepatitis
Inflammation of the liver
What do we have to monitor for a TB patient on treatment
The liver
how can we control Tb
Housing
Overcrowding
Nutrition
Immunisation
What is bronchiestasis
A condition whereby you get chronic bronchial dilation that leads to poor mucus clearance which leads to recurrent or chronic infection and infection causes more chronic bronchial dilation
What are the common causes of bronchiectasis
Previous pnuemonia or TB
What are the symptoms of bronchiestasis
Coughing up large volume of flem
Crackles in chest in inspiration and expiration
What are the other causes apart from infection to bronchiestasis
Aspiration e.g peanut Mechanical obstruction Immune deficient Rheumatoid arthritis Cystic fibrosis Primary ciliary dyskinesia
How do we treat bronchiestasis
Treat the underlying cause
How do we investigate bornchiectasis
Chest x-ray
Sputum culture
CT scan
How do we manage bronchiestasis
Postural drainage
Antibiotics
Bronchodilators
What is cystic fibrosis
A mutation to the deltaf506 deletion to CFTR
What type of channel is CFTR
Chloride channel
What does cystic fibrosis lead to
Steaky secretions
What are the other consequences of cystic fibrosis apart from bronchiestasis
Pancreatic insufficiency
Infertility
How do we investigate cystic fibrosis
Sweat test
Genetic testing
What is the management for cystic fibrosis
Aggressive management of bronchiectasis Pancreatic enzyme supplements Insulin Nutrients Lung transplantation
What are the diseases where infection can cause flare ups
COPD exacerbation
Asthma exacerbation
What are the symptoms of exacerbated COPD
Increased breathlessness
Green sputum
Increased sputum volume
How do we treated exacerbated COPD
Antibiotics for 5 day
Or
Steroids (severe)
How is exacerbation of asthma treated
Steroid