L15: Neurological And Vascular Aspects Flashcards
What detects the changes in pac02
Central chemoreceptors
where are central chemoreceptors located
In medulla oblongata
What detects the changes to pao2 and blood ph
Peripheral chemoreceptors
Where are peripheral chemoreceptors located
In carotid/aortic arch
Where does the chemoreceptors in the medulla oblongata and carotid/aortic arch send nerve supply to
Brainstem respiratory centre
What does the brainstem respiratory centre do
Change the activity of the muscles to change alveolar ventilation and respond the the changes in blood
Describe what happens when the we excercise and paco2 increases and pao2 decreases
1) changes are detected by central chemoreceptors and peripheral chemoreceptors
2) signal is sent to the brainstem respiratory centre
3) signal is sent to the diaphragm and intercostal muscle to increase the rate of ventilation
3) carbon dioxide levels drop and oxygen levels increase
What does injury to the brain most likely to result in
Affect breathing
What can a tumour in the brainstem cause
Pressure on the medulla oblongata so chemoreceptors are blocked off and breathing stops
What other brainstem lesions can compress the brain
Haemorrhage (bleeding)
Ischaemia
What is ischaemia
Swelling of the brain
What type of drugs can affect breathing
Sedative drugs
What do sedative drugs do
Reduce the respiratory drive
Reduce ventilation
Example of sedative drugs
Morphine
Opiates
Benzodiazepines
What are sedative drugs
A group of drugs that slow down brain activity
What other diseases can affect ventilation
Neuromuscular disease
Examples of neuromuscular disease
Motor neurone disease
Duschennes muscular dystrophy
What is motor neurone disease
Degeneration of ventral horns in the spinal cord where the upper motor neurone and lower motor neurone meet
Where does the symptoms for motor neurone disease usually start
Limbs
Swallowing muscles
In terms of IRM what does motor neurone disease result in
Diaphragm weakness
Poor swallowing