Kreb Cycle Flashcards
Step 2
Citrate is
Isomerized by
Transfer of OH group to yield
Isocitrate
Step 1
Acetyl group is transferred from
Acetyl-SCoA
To
Oxaloacetate
Produced in step 8
Step 3
Isocitrate loses
CO2
And is
Oxidized to yield
Alpha- ketoglutarate
Step 4
Alpha-ketoglutarate
Reacts with
Coenzyme A
And loses
CO2 to yield
Succinyl-SCoA
Step 5
Succinyl-CoA is set
Free to give Succinate Plus CoA In a reaction coupled with ATP formation
Step 6
Two hydrogens
Are removed from
Succinate
To yield
Fumarate
Step 7
Addition of water
To the double bond of
Fumarate yields
Malate
Step 8
The cycle of reactions
Is completed by
Oxidation of malate to
Regenerate
Oxaloacetate
Acetyl CoA available from the
Breakdown of
Carbohydrates
Lipids
Amino acids
Acetyl CoA is the
Fuel of the citric acid cycle
The operation of the cycle requires a supply of the
Oxidizing agents
NAD and FAD
The cycle is dependent on
Reactions of the electron transport chain
the electron transport chain supplys
The necessary
NAD
FAD
In each turn of the cycle
Acetyl CoA enters and two fully oxidized carbon molecules leave as CO2
Acetyl-CoA
From the
Glycolytic pathway
or
From fatty acid catabolism