Drugs

Question 0

Opiates : opium

Answer 0

1. Morphine
2. Codeine
3. Heroin

Question 1

Opiates: description

Answer 1

Narcotic analgesic
Addictive
Habit forming

Question 2

Morphine: composition

Answer 2

Fits into receptor sites on neurons in the brain and spinal cord

Question 3

Morphine:

Answer 3

Receptor site (similar drugs sit)

Difference between morphine and codeine is very small

Question 4

Codeine

Answer 4

Prescription cough syrup

Enzyme (clieves off ether turns into morphine)

Converted to morphine

Question 5

Heroine

Answer 5

Morphine and esters (not polar, no H-bonds. Esters)

100x easier to pass BBB

Very addictive

Question 6

Synthetic opiates

Answer 6

Add addictive milder than morphine

Question 7

Demerol

Answer 7

Shot

Synthetic opiate

Question 8

Hydrocodone

Answer 8

Percodan
Percoset
OxyContin (10 x time release)

Synthetic opiates

Question 9

Addiction

Answer 9

1. Psychological dependence
2. Physiological dependence
3. Tolerance

Question 10

Psychological dependence

Answer 10

Uncontrolled desire for drug

Question 11

Physiological dependence

Answer 11

Body need the drug

Question 12

Withdrawal

Answer 12

Leads to convulsions

More dangerous than drug

Question 13

Tolerance

Answer 13

User increases dosage to get the same effect.

Body decreases number of receptor sites (defense against drug)

Question 14

Cocaine is worse. Why

Answer 14

Dopamine

Decrease receptors

Depression

Question 15

Narcotic analgesics

Answer 15

Morphine

Demerol

Oxycodon: Percodan
Percosel
OxyContin
Fentanyl patch

Question 16

Fentanyl patch

Answer 16

80% stronger than morphine

Question 17

Antagonist

Answer 17

Molecule that BLOCKS the receptor for a drug neurotransmitter

Question 18

Agonist

Answer 18

Molecule MIMICS the action of the drug or neurotransmitter

Question 19

Treatment of addiction

Answer 19

Methadone

Naloxone

Question 20

Methadone

Answer 20

Highly addictive

Clinic

Treat heroin overdose

Question 21

Naloxone

Answer 21

Antagonist to heroin
(Blocks the receptor)

No high associated

Question 22

Why we have opiate receptors

Answer 22

Body has own opiates (pain killers)

Question 23

Produce opiates

Answer 23

Endorphins

Enkaphalins

(Receptors)

Question 24

Endorphins

Answer 24

1. Respond to pain DEEP in the body. Wound (kills pain)
2. Runners “high” ~ strenuous physical activity
3. Acupuncture~ deep, produce endorphins

Question 25

Enkephalins

Endorphins

Answer 25

Acts as pain blockers

Produced by the body

Involved in pain perception

Inhibits intestinal motility

Question 26

Morphine

Answer 26

• -One of the most effective painkillers
• -Acts by blocking the process in the brain that interprets pain signals from peripheral nervous system

Brain has receptor sites for the body own opiates (enkephalins) and morphine fits into those receptor sites

Question 27

Codeine

Answer 27

Less potent than morphine

Used in cough syrup

Enzyme that converts the codeine into morphine

Question 28

Oxycodone and Hydrocodone

Answer 28

Synthetic pain killer

Found in Percodan
Percocet
Oxycotin

Question 29

Heroin

Answer 29

Illegal drug produced from morphine

3x more potent than morphine (ability to move through the BBB)

More addictive than morphine used in Bayer aspirin products 1880s

Question 30

Naloxone

Answer 30

Used to treat heroin overdoing

Blocks receptors sites for opiates
Antagonist

Question 31

Buprenorphine

Answer 31

Helps with opiate addictions

Binds to same sites as heroin but with no “high”

Less addictive and easier withdrawal