KA1- Control of metabolic pathways Flashcards
What are metabolic pathways controlled by?
Presence/ absence of certain enzymes
Regulation of the rate if reaction of key enzymes
What do pathways often contain?
Reversible or irreversible steps, allowing precise control
What are multi-enzyme complexes?
The groups of enzymes working in sequence in metabolic pathways
How can pathways be controlled?
Gene expression
What is an inhibitor?
A substance that decreases the rate of an enzyme controlled reaction
What are the two types of inhibitors?
Competitive
Non-competitive
Why do competitive inhibitors compete with the substrate?
As they have a similar molecular structure to the substrate
Shat do competitive inhibitors compete with?
The substrate for the active site on the enzyme
Why do competitive inhibitors decrease ROR?
As it blocks the active site of some enzyme molecules, so the substrate can!r fit in
How do non-competitive inhibitors work?
They attach away from the active site and changes the shape of the enzyme. This alters the shape of the active site so the substrate no longer fits
What is feedback inhibition?
When the end product in the metabolic pathway reaches critical condition
What do feedback inhibitors bind to?
An enzyme which catalyses a reaction early in the pathway and acts as a non-competitive inhibitor, changing its shape and blocking off the pathway
