Jan 27 Treatments for type 2

Question 1

What is the biology behind T2D?

(Name 2)

Answer 1

What is the biology behind T2D?

1. Insulin resistance
2. Inability to produce ENOUGH insulin to keep glucose in the normal range
   (~4-9 mmol/l)

Question 2

◦ What is Prediabetes ?

A diagnosis of prediabetes: (Name 3)

Answer 2

◦ Prediabetes is when glucose levels are not in the normal range.

For a diagnosis of prediabetes,

Morning fasted glucose is in the pre-diabetes range (called impaired fasting glucose: 6.1 to 6.9 mmol/L),

OGTT is elevated (impaired glucose tolerance: 2 hr glucose between 7.8 to 11.0 mmol/L),

HbA1c test is between 6.0% to 6.4%.

Question 3

___%-% energy from complex carbs

Answer 3

50-60% energy from complex carbs

Question 4

The most effective treatment for diabetes prevention in those already diagnosed with pre-diabetes is?

The reduction in risk of developing T2D with lifestyle was? (2 things)

Answer 4

The most effective treatment for diabetes prevention in those already diagnosed with pre-diabetes was lifestyle modification causing weight loss.

The reduction in risk of developing T2D with lifestyle was ~68% with lifestyle vs placebo and only about 20% with metformin.

Question 5

~___ different classifications of medications for T2D

Answer 5

~12 different classifications of medications for T2D

Question 6

Metformin
Mechanism: (2 things)

Answer 6

Mechanism:
* Reduces liver glucose production
* Increases insulin sensitivity in muscle and fat tissue.