Jan 22 Type 1 Diabetes

Question 1

“The Pissing Evil” is refer to as ______

Before _____ _____, a diagnosis of _____ diabetes (now called Type 1 diabetes) was a _____ _____.

Answer 1

“The Pissing Evil” is refer to as Type 1 Diabetes

Before January 1922, a diagnosis of Juvenile diabetes (now called Type 1 diabetes) was a death sentence.

Question 2

Symptoms included

• Weight _____
• Frequent _____
• “_____” urine
• Physical Exhaustion
• _____ smelling breath
• Coma, death

Fruity breath is because of the _____ and _____

Answer 2

Symptoms included

• Weight loss
• Frequent urination
• “Sweet” urine
• Physical Exhaustion
• Sweet smelling breath
• Coma, death

Fruity breath is because of the Ketone and burning fat

Question 3

On Jan. 22, 1922, Leonard was
injected with an experimental
treatment called _____ (later
called _____).

Answer 3

On Jan. 22, 1922, Leonard was
injected with an experimental
treatment called isletin (later
called insulin).

Question 4

Type 1 Diabetes
Formally _____ Diabetes or _____-_____ Diabetes)

An _____-based _____ disease that requires _____ to live!

Answer 4

Type 1 Diabetes
Formally Juvenile Diabetes or Insulin-dependent Diabetes)

An autoimmune-based metabolic disease that requires insulin to live!

Question 5

Diagnosis rates of type 1 diabetes by age and sex

Type 1 diabetes can be
diagnosed at any age but
the highest incidence rate
for diagnosis is in the
_____ years
* ~____% chance of
developing T1D in your
teens

Answer 5

Diagnosis rates of type 1 diabetes by age and sex

Type 1 diabetes can be
diagnosed at any age but
the highest incidence rate
for diagnosis is in the
teen years
* ~0.05% chance of
developing T1D in your
teens

Question 6

Pathogenesis of Type 1 Diabetes

The basic pathophysiology is the _____ destruction of _____ cells and a _____ in beta cell _____
A) _____ susceptibility
B) _____ factors
C) Certain _____ factors (i.e., triggers for the immune system such as a virus or illness)

Answer 6

Pathogenesis of Type 1 Diabetes

The basic pathophysiology is the autoimmune destruction of beta cells and a loss in beta cell mass
A) Genetic susceptibility
B) Autoimmune factors
C) Certain environmental factors (i.e., triggers for the immune system such as a virus or illness)

Question 7

Genetic link and Environmental Triggers

*Identical twin studies show a
_____ link
✔ If one twin has type 1 diabetes, the
likelihood that the other has type 1
is ~_____

*No single _____ trigger is
proven…but several possible
triggers exist…

Answer 7

Genetic link and Environmental Triggers

*Identical twin studies show a
genetic link
✔ If one twin has type 1 diabetes, the
likelihood that the other has type 1
is ~50%

*No single environmental trigger is
proven…but several possible
triggers exist…

Question 8

Symptoms of Type 1 Diabetes

include:
* Increased _____
* Frequent _____
* Bed-wetting in children who previously didn’t wet the bed during the night
* Extreme _____
* Unintended weight loss
* Irritability and other mood changes
* _____ and weakness
* Blurred vision
* A strong, fruity breath odor (_____)

Answer 8

Symptoms of Type 1 Diabetes

include:
* Increased thirst
* Frequent urination
* Bed-wetting in children who previously didn’t wet the bed during the night
* Extreme hunger
* Unintended weight loss
* Irritability and other mood changes
* Fatigue and weakness
* Blurred vision
* A strong, fruity breath odor (ketones)