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FCPH > introduction to HIV > Flashcards

introduction to HIV Flashcards

1
Q

what family does HIV belong to ?

A

retroviriade

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2
Q

what is HIV1 originally cause by

what is HIV 2 originally caused by ?

A

HIV1 - SIC chimpanzees

HIV 2 - SIV SM

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3
Q

what are the clinical stages of HIV infection ?

A
  1. an early acute stage
  2. middle clinical latency stage
  3. late immunodeficiency stage
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4
Q

what are the features of the the early acute stage ?

A 
fever 
fatigue 
myalgia 
GI symp 
Lymphadenopathy
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5
Q

what are the features of the middle clinical latency stage ?

A

early - minimal or no symptoms

late - onset of constitutional symptoms

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6
Q

what are the features of the late immunodeficiency stage ?

A

severe constitutional symptoms

opportunistic infections

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7
Q

what are the different targets stages in the replication of HIV ?

A 
entry inhibitors 
fusion inhibitors 
nukes 
non nukes 
protease inhibitors 
integrase inhibitors
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8
Q

what is the mechanism of entry inhibitors ?

A

CCR5 blockers

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9
Q

what is the name of the CCR5 blocker ?

A

maraviroc

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10
Q

what does CD4 on T cells fuse with on HIV cells ?

A

gp 120

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11
Q

what is the purpose of CCR5 on T cells ?

A

acts as a co receptor for HIV

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12
Q

what is the importance of check for CRR5 and CXR4 on T cells ?

A

CCR5 - usually early in the disease

CXR4 - usually later in the disease

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13
Q

what are the nuke drugs ?

A

zidovudine
lamivudine
tenofovir

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14
Q

what are the non-nuke drugs ?

A

efavirenez

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15
Q

what are the integrase inhibitors ?

A

raltegravir

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16
Q

what are the protease inhibitors ?

A

all end with navir

17
Q

what are the principles of treatment regarding HIV ?

A

no cure only suppression of replication
mono therapy not suggested - use instead HAART
Ab prophylaxis in AIDS patients

18
Q

what are the treatment goals ?

A

increasing the count of CD4

reducing the viral load

19
Q

how is the monitoring of anti-HIV therpay done ?

A

through monitoring of viral load

CD4 cell count

20
Q

when can PCP prohylaxis be stopped ?

A

once CD4 count is over 200

21
Q

how long is HAART meant to be taken for ?

A

a lifelong treatment

22
Q

when should resistance testing be performed ?

A

prior to HAART

at each HAART switch when previous HAART failed

23
Q

what medication is used for pneumocystis prophylaxis ?

A

cotrimoxazole

FCPH (39 decks)

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