HIV and the immune system Flashcards
what are the HIV target cells ?
CD4
macrophages
APC
what does the CD4 pool consist off ?
naive cells
central memory cells
effector memory cells
what are the features of CD4 cells in the naive pool ?
in the thymus
CCR5 negative and are immune to HIV infection
what are the features of the central memory CD4 cells ?
mostly CCR5 negative
mostly CXR4 positive
they re-circulate among secondary lymphoid tissues
what are the features of CD4 cells in the effector memory pool ?
CD4 cells express high levels of CCR5
what are the serological features of primary HIV infection n?
initial rapid rise in plasma viremia
decrease inn blood CD4 count especially gut associated
increase in CD8 count
high levels of immune activation
when does HIV evade the immune system ?
during the PIH stage
what does CD4 on t cells bind to ?
gp 120
what does gp 41 on HIV cells bind to ?
GP120 to form HIV spike trimers on the surface of HIV particles
what does a tropism switch mean ?
switch from CCR5 to CXR4
when is the best time to control HIV and to give the best long time progression on HAART ?
during the PHI
what are elite controllers ?
HIV infected individuals who manage to keep their viral load low for the first 12 months of infection without the use of HAART
when does seroconverion happen along the course of HIV infection ?
after the acute stage or the initial HIV infection
what are the first markers of HIV infection ?
antibodies to p24 and antibodies to gp 41
