Important Info Remembered Pharm ex 2

Question 1

What is the conduction pathway of the heart?

Answer 1

SA, AV, Bundle of His, Purkinje

Question 2

Inflow of potassium is part of which phase of the action potential

Answer 2

3

Question 3

Which is the phase where you can’t have an action potential no matter what?

Answer 3

Absolute refractory

Question 4

Which class is Na channel blockers?

Answer 4

Class I

Question 5

What is the most commonly reported allergic reaction

Answer 5

skin

Question 6

What do you do when someone has an adverse reaction to a drug?

Answer 6

a. Give them something to take care of the adverse reaction
b. Stop giving them the drug

…not sure which is correct (prolly b)

Question 7

Which is a pure alpha 1 agonist?

Answer 7

Phenylephrine

Question 8

Which of the following would lessen the effects of a beta antagonist

Answer 8

A beta agonist

Question 9

Which is given for short-term asthma attacks?

Answer 9

Albuterol

Question 10

Which drug has a bunch of anticholinergic effect such as decreased salivary flow?
a. Lido
b. K+ channel blockers
c. Na+ channel blockers

Answer 10

c. Na+ channel blockers

Question 11

Which class of drugs do you have to watch for gingival hyperplasia?

Answer 11

IV

Question 12

Which is a dihydropyridine drug

Answer 12

Ends in dipine

Question 13

Which drug do you have to be careful not to shine light in patient’s eyes

Answer 13

Amiodarone

Question 14

Which of the following is not a liver enzyme?

Answer 14

3A4???

Question 15

Cardiac output is a product of stroke volume and what else

Answer 15

heart rate

Question 16

Which drug increases patient’s gag reflex?

Answer 16

Digoxin

Question 17

Which drug inhibits PDE-3

Answer 17

Milrinone

Question 18

All of the following determine MVO2 except

Answer 18

Hemoglobin

These things DO
1. Heart rate
2. Myocardial contractility
3. Myocardial wall stress

Question 19

Which of the following improves angina by changing BP or HR?

Answer 19

This might have been mis-worded and the answer was Ranolazine?

Ranolazine- improves angina w/o changing BP or HR

Question 20

Which drug is good for nasal spray and something else?

Answer 20

Organic nitrates

test file had no answer but this might be it

Question 21

Which metabolises NE and Epi?

Answer 21

MAO

Question 22

Which is correct about the sympathetic nervous system

Answer 22

Short preganglionic fibers and long postganglionic fibers

Question 23

What is a cholinergic fiber

Answer 23

Fiber that secretes Ach

Question 24

Which of the following is true about somatic nervous system

Answer 24

It is what handles posture, respiration, I can’t remember

• VOLUNTARY
• CONTROLS MOVEMENT, RESPIRATION, POSTURE
• ALWAYS EXCITATORY
• NO GANGLIA

Question 25

Ach is made when acetyl CoA and choline come together in

Answer 25

The cytoplasm

Question 26

Which of the following muscarinic receptors is the cardiac receptor?

Answer 26

M2

Question 27

A couple of basic questions about what sympathetic and parasympathetic do to heart rate, salivary flow, etc.

Answer 27

SYMPATHETIC (SANS) * FIGHT OR FLIGHT * RUNS ON NOREPINEPHRINE * INCREASES CO, BP, RR, BLOOD FLOW, BG * DECREASES RBF, DIGESTIVE PROCESSES * FIRES AT ONCE * SHORT PRE-, LONG POST PARASYMPATHETIC (PANS) * NORMAL MAINTENANCE AND ANABOLIC METABOLISM * INCREMENTAL ACTIVATION * VAGAL STIMULATION * LONG PRE-, SHORT POST

Question 28

Which of the following is a depolarizing neuromuscular blocker

Answer 28

Succinylcholine

Question 29

Myasthenia gravis is treated with

Answer 29

Indirect acting anticholinergics

Question 30

Cevimiline is used for

Answer 30

a. Post-surgical urinary retention—this was wrong b. Should be something about sjogren’s ## Footnote slides say... Cevimiline * SELECTIVE FOR M3 * MORE SELECTIVE FOR EXOCRINE GLANDS * RADIATION-INDUCED XEROSTOMIA; SJOGREN’S SYNDROME

Question 31

Which of the following has anticholincergic effects without an effect on the CNS?

Answer 31

Glycopyrrolate | also TIOTROPIUM

Question 32

Which of the following is a quaternary amine?

Answer 32

Glycopyrrolate | also TIOTROPIUM

Question 33

Defining pharmacokinetic

Answer 33

*INTERACTION THAT CHANGES THE BASIC KINETIC PROPERTIES - ABSORPTION - DISTRIBUTION - METABOLISM - ELIMINATION

Question 34

Defining pharmacodynamics

Answer 34

*INTERACTION BETWEEN 2 OR MORE DRUGS THAT LEADS TO - ACCENTUATION/SYNERGISM - ATTENUATION/ANTAGONISM *DON’T DIRECTLY INVOLVE ABSORPTION, DISTRIBUTION, METABOLISM, OR EXCRETION

Question 35

Which phase of metabolism is not sensitive to aging?

Answer 35

no answer is given on file... maybe phase 1 ## Footnote This would be phase 2. phase 1 is sensitive to aging

Question 36

When we have two drugs competing for protein binding, we have a transient increase in a. Bound drug b. Free unbound drug c. Drug concentration d. No change

Answer 36

no answer on the file... maybe b. Free unbound drug

Question 37

Some question about metabolites

Answer 37

Prozac and paxil ## Footnote these two drugs are listed under "Antidepressant CYP450 Substrates" but he said not to memorize that slide

Question 38

If you give someone opiates and that slows their GI emptying, what will that do the the absorption of drugs?

Answer 38

Slows it

Question 39

Tetracycline can have a reaction with what in the gut that will changedistribution

Answer 39

iron ## Footnote calcium and iron bind with tetracycline

Question 40

Which drug causes gingival hyperplasia?

Answer 40

Phenatoin

Question 41

Which of the following results from non-covalent toxicity?

Answer 41

all of the above ## Footnote - Lipid peroxidation - Reactive oxygen species - Depletion of glutathione - Modification of sulfhydryl groups

Question 42

Cancer usually happens when there has been a problem with which two things?

Answer 42

proto-onco and tumor suppressor genes

Question 43

Alpha 1 does what?

Answer 43

peripheral vasoconstriction and increase BP

Question 44

Beta 2 agonist does what?

Answer 44

bronchodilation | beta-2 inhibitor is an agonist? I'm kinda confused on this

Question 45

What is the best way to give epi in an anaphylactic reaction?

Answer 45

intramuscularly | not sure where we learned this

Question 46

Which of the following is a push dose pressor?

Answer 46

phenylephrine

Question 47

Which anti-angina med works by inhibiting the breakdown of cAMP?

Answer 47

milrinone