Important Info Remembered Pharm ex 2 Flashcards
What is the conduction pathway of the heart?
SA, AV, Bundle of His, Purkinje
Inflow of potassium is part of which phase of the action potential
3
Which is the phase where you can’t have an action potential no matter what?
Absolute refractory
Which class is Na channel blockers?
Class I
What is the most commonly reported allergic reaction
skin
What do you do when someone has an adverse reaction to a drug?
a. Give them something to take care of the adverse reaction
b. Stop giving them the drug
…not sure which is correct (prolly b)
Which is a pure alpha 1 agonist?
Phenylephrine
Which of the following would lessen the effects of a beta antagonist
A beta agonist
Which is given for short-term asthma attacks?
Albuterol
Which drug has a bunch of anticholinergic effect such as decreased salivary flow?
a. Lido
b. K+ channel blockers
c. Na+ channel blockers
c. Na+ channel blockers
Which class of drugs do you have to watch for gingival hyperplasia?
IV
Which is a dihydropyridine drug
Ends in dipine
Which drug do you have to be careful not to shine light in patient’s eyes
Amiodarone
Which of the following is not a liver enzyme?
3A4???
Cardiac output is a product of stroke volume and what else
heart rate
Which drug increases patient’s gag reflex?
Digoxin
Which drug inhibits PDE-3
Milrinone
All of the following determine MVO2 except
Hemoglobin
These things DO
1. Heart rate
2. Myocardial contractility
3. Myocardial wall stress
Which of the following improves angina by changing BP or HR?
This might have been mis-worded and the answer was Ranolazine?
Ranolazine- improves angina w/o changing BP or HR
Which drug is good for nasal spray and something else?
Organic nitrates
test file had no answer but this might be it
Which metabolises NE and Epi?
MAO
Which is correct about the sympathetic nervous system
Short preganglionic fibers and long postganglionic fibers
What is a cholinergic fiber
Fiber that secretes Ach
Which of the following is true about somatic nervous system
It is what handles posture, respiration, I can’t remember
- VOLUNTARY
- CONTROLS MOVEMENT, RESPIRATION, POSTURE
- ALWAYS EXCITATORY
- NO GANGLIA
Ach is made when acetyl CoA and choline come together in
The cytoplasm
Which of the following muscarinic receptors is the cardiac receptor?
M2
A couple of basic questions about what sympathetic and parasympathetic do
to heart rate, salivary flow, etc.
SYMPATHETIC (SANS)
* FIGHT OR FLIGHT
* RUNS ON NOREPINEPHRINE
* INCREASES CO, BP, RR, BLOOD FLOW, BG
* DECREASES RBF, DIGESTIVE PROCESSES
* FIRES AT ONCE
* SHORT PRE-, LONG POST
PARASYMPATHETIC (PANS)
* NORMAL MAINTENANCE AND ANABOLIC METABOLISM
* INCREMENTAL ACTIVATION
* VAGAL STIMULATION
* LONG PRE-, SHORT POST
Which of the following is a depolarizing neuromuscular blocker
Succinylcholine
Myasthenia gravis is treated with
Indirect acting anticholinergics
Cevimiline is used for
a. Post-surgical urinary retention—this was wrong
b. Should be something about sjogren’s
slides say…
Cevimiline
* SELECTIVE FOR M3
* MORE SELECTIVE FOR EXOCRINE GLANDS
* RADIATION-INDUCED XEROSTOMIA; SJOGREN’S SYNDROME
Which of the following has anticholincergic effects without an effect on the CNS?
Glycopyrrolate
also TIOTROPIUM
Which of the following is a quaternary amine?
Glycopyrrolate
also TIOTROPIUM
Defining pharmacokinetic
*INTERACTION THAT CHANGES THE BASIC
KINETIC PROPERTIES
- ABSORPTION
- DISTRIBUTION
- METABOLISM
- ELIMINATION
Defining pharmacodynamics
*INTERACTION BETWEEN 2 OR MORE DRUGS THAT LEADS TO
- ACCENTUATION/SYNERGISM
- ATTENUATION/ANTAGONISM
*DON’T DIRECTLY INVOLVE ABSORPTION, DISTRIBUTION, METABOLISM, OR EXCRETION
Which phase of metabolism is not sensitive to aging?
no answer is given on file…
maybe phase 1
This would be phase 2. phase 1 is sensitive to aging
When we have two drugs competing for protein binding, we have a transient increase in
a. Bound drug
b. Free unbound drug
c. Drug concentration
d. No change
no answer on the file…
maybe b. Free unbound drug
Some question about metabolites
Prozac and paxil
these two drugs are listed under “Antidepressant CYP450 Substrates” but he said not to memorize that slide
If you give someone opiates and that slows their GI emptying, what will that do the the absorption of drugs?
Slows it
Tetracycline can have a reaction with what in the gut that will changedistribution
iron
calcium and iron bind with tetracycline
Which drug causes gingival hyperplasia?
Phenatoin
Which of the following results from non-covalent toxicity?
all of the above
- Lipid peroxidation
- Reactive oxygen species
- Depletion of glutathione
- Modification of sulfhydryl groups
Cancer usually happens when there has been a problem with which two things?
proto-onco and tumor suppressor genes
Alpha 1 does what?
peripheral vasoconstriction and increase BP
Beta 2 agonist does what?
bronchodilation
beta-2 inhibitor is an agonist? I’m kinda confused on this
What is the best way to give epi in an anaphylactic reaction?
intramuscularly
not sure where we learned this
Which of the following is a push dose pressor?
phenylephrine
Which anti-angina med works by inhibiting the breakdown of cAMP?
milrinone
