Important Info 2.3 exam 3 Flashcards by Pickle Rick

Which medication (s) binds to factor Xa and prevents the conversion of prothrombin to thrombin?
A. Bivalirudin (Angiomax)
B. Dabigatran (Pradaxa)
C. Rivaroxaban (Xarelto)
D. All the above

C. Rivaroxaban (Xarelto)

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Which of the following is a/are components of Virchow’s triad?
A. Aggregation
B. Vessel wall injury
C. von Willebrand factor
D. All the above

B. Vessel wall injury
a. Stasis of blood and hypercoagulability

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Pulmonary hypertension caused by left heart disease is classified as which group per the world health organization?
A. Group I
B. Group Il
C. Group IlI
D. Group IV

B. Group Il

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Which of the following medications has possible visual side effects which can be aggravated by the dental light?
A. Alirocumab (Praluent)
B. Bempedoic acid (Nexletol)
C. Colesevelam (Welchol)
D. Gemfibrozil (Lopid)

D. Gemfibrozil (Lopid)

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Which of the following medications would be least likely to have a significant drug-drug interaction due to hepatic metabolism?
A. Atorvastatin (Lipitor)
B. Pravastatin (Pravachol)
C. Rosuvastatin (Crestor)
D. B and c

D. B and c

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Which of the following is an adverse reaction to aspirin (Bayer)?
A. Angioedema
B. Bleeding
C. Rash
D. All the above

D. All the above

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How does LovaSTATIN (Mevacor) exert its lipid lowering activity?
A. Binding to bile acid and preventing resorption
B. Binding to PARa nuclear receptor increasing lipoprotein lipase levels
C. Blocking transport protein NPC1L1 in the brush border of the enterocyte.
D. Inhibition of HMG-CoA reductase

D. Inhibition of HMG-CoA reductase

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Which substance is thought to contribute to the development of cough in patients on ACE inhibitors?
A. Bradykinin
B. Kininase II
C. pro-BNP
D. Renin

A. Bradykinin

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Which medication (s) causes the activation of antithrombin III?
A. Dabigatran (Pradaxa)
B. Enoxaparin (Lovenox)
C. Unfractionated heparin
D. B and C

D. B and C

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Which of the following medications works through antagonist of the protease activated receptor-1 inhibiting
thrombin receptor agonist peptide (TRAP)?
A. Alteplase (Activase)
B. Aspirin (Bayer)
C. Ticagrelor (Brilinta)
D. Vorapaxar (Zontivity)

D. Vorapaxar (Zontivity)

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Which of the following medications can cause a severe adverse drug reaction called angioedema (swelling of the throat, tongue, and lips)?
A. Minoxidil (Loniten)
B. Sacubitril/Valsartan (Entresto)
C. Selexipag (Uptravi)
D. Band C

B. Sacubitril/Valsartan (Entresto)

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What receptor does losartan (Cozaar) block?

A. AT1 receptor
B. Endothelin
C. Renin
D. Prostacyclin

A. AT1 receptor

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Which of these medications may increase triglycerides?

A. Colestipol (Colestid)
B. Ezetimibe (Zetia)
C. Fenofibrate (Tricor)
D. Niacin (Niaspan)

A. Colestipol (Colestid)

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The intracellular concentration of which ion is key to determining smooth muscle tone?
A. Calcium
B. Potassium
C. Phosphate
D. Sodium

A. Calcium

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The patient is a 46-year-old Caucasian woman that smokes and has diabetes mellitus. How many risk factors for atherosclerotic cardiovascular disease are present in this patient?
A. One
B. Two
C. Three
D. Four

B. Two

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Bempedoic acid (Nexletol) exerts lipid lowering activity through which mechanism?
A. Binding to bile acid and preventing resorption
B. Binding to PARa nuclear receptor increasing lipoprotein lipase levels
C. Inhibition of ATP-citrate Iyase (ACL)
D. Inhibition of HMG-CoA reductase

C. Inhibition of ATP-citrate Iyase (ACL)

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Minoxidil (Loniten) causes vasodilation by:
A. Activation of adenylyl cyclase
B. Inhibition of angiotensin converting enzyme
C. Interference with IP (inositol triphosphate, aka IP3) action on the sarcoplasmic reticulum
D. Opening KATP channels

D. Opening KATP channels

Which of the following medications and doses would be considered a “moderate intensity” statin?
A. Atorvastatin (Lipitor) 10mg
B. Atorvastatin (Lipitor) 40mg
C. Rosuvastatin (Crestor) 40mg
D. B and C

A. Atorvastatin (Lipitor) 10mg

Which of the following medications for pulmonary hypertension is available in an intravenous formulation?
A. Bosentan (Tracleer)
B. lloprost (Ventavis)
C. Treprostinil (Tyvaso)
D. B and C

C. Treprostinil (Tyvaso)

Riociguat (Adempas) can be classified in which group based on mechanism of action?

A. Endothelin receptor antagonist (ERA) - Bosentan
B. Phosphodiesterase 5 (PDE5) inhibitor – Sildenafil
C. Selective prostacyclin IP receptor agonist – Selexipag
D. Soluble guanylate cyclase stimulator

D. Soluble guanylate cyclase stimulator

Which of the following is a/(are) a potential adverse reaction(s) to atorvaSTATIN (Lipitor)?
A. Flushing
B. Gastrointestinal (GI) distress
C. Myopathy
D. A and B

C. Myopathy

Which medication is monitored by the prothrombin time (PT) International Normalized Ratio (INR)?
A. Argatroban
B. Unfractionated heparin
C. Warfarin (Coumadin)
D. A and B

C. Warfarin (Coumadin)

Which lipoprotein contains the most triglycerides?
A. Chylomicrions
B. HDL
C. LDL
D. VLDL

A. Chylomicrions

Which of the following medication classes may cause hyperuricemia (Elevated uric acid)?
A. ATP-citrate lyase (ACL) inhibitor
B. Bile Acid Binding Agents (BABA)
C. Fibrates
D. HMG-CoA reductase inhibitors

A. ATP-citrate lyase (ACL) inhibitor

Which of the following medications can have injection site reactions? A. Colestipol (Colestid) B. Evolcumab (Repatha) C. Ezetimibe (Zetia) D. Niacin (Niaspan)

B. Evolcumab (Repatha)

Which of the following medications inhibit the action of phosphodiesterase 5 (PDE5)? A. Bosentan (Tracleer) B. Epoprostenol (FlolanNeleti) C. Tadalafil (Adcirca) D. Aand

C. Tadalafil (Adcirca)

Which of the following is a vitamin K dependent clotting factor? A. Factor III B. m Factor VIlI C. Factor X D. A and c

C. Factor X

Which of the following medications can be given intravenously? A. Bivalirudin (Angiomax) B. Cangrelor (Kengreal) C. Unfractionated heparin D. All of the above

D. All of the above

Which antiplatelet medication works thru inhibition of ADP binding at the P2Y 12 receptor)? A. Aspirin (Bayer) B. Prasugrel (Effient) C. Tirofiban (Aggrastat) D. Vorapaxar (Zontivity) – PAR-1 antagonist

B. Prasugrel (Effient)

Eplerenone (Inspra) works by competitively blocks the action of which hormone? A. Aldosterone B. Endothelin-1 C. Neprilysin D. Nitric oxide

A. Aldosterone

Which lipoprotein is considered the "good cholesterol"? A. Chylomicrions B. HDL C. LDL D. VLDL

B. HDL

Which medication has a risk of hyperkalemia? A. Hydralazine (Apresoline) B. Sacubitril/Valsartan (Entresto) C. Spironolactone (Aldactone) D. B and C

D. B and C

Eptifibatide (Integrilin) inhibits which step in thrombus formation? A. Conversion of factor VII to factor VIlla B. Conversion of plasmin to plasminogen C. Platelet activation D. Platelet aggregation

D. Platelet aggregation

The glycoprotein lIb/Illa receptor is involved in which step of platelet thrombus formation? A. Activation B. Adhesion C. Aggregation D. Fibrin

C. Aggregation

Which of the following medications prevents the conversion of angiotensin I to angiotensin II? A. Aliskiren (Tekturna) B. Quinapril (Accupril) C. Telmisartan (Micardis) D. Sacubitril/Valsartan (Entresto)

B. Quinapril (Accupril)

Which of the following is a/are positive "pleiotropic effect(s)" of HMG-CoA reductase inhibitors? A. Immune suppression B. Inhibition of germ cell migration C. Reduced inflammation D. All the above

C. Reduced inflammation

Which of the following is a unique side effect of minoxidil (Loniten)? A. Gingival hyperplasia B. Hirsutism (hair growth) C. Hyperkalemia D. Jaw pain

B. Hirsutism (hair growth)

"Purple Toe" syndrome is a potential adverse reaction to which of the following medications? A. Argatroban B. Aspirin (Bayer) C. Tirofiban (Aggrastat) D. Warfarin (Coumadin)

D. Warfarin (Coumadin)

What is the mechanism of action of aminocaproic acid (Amicar)? A. Competitive inhibition of plasminogen activation B. Convert of fibrin to fibrinogen C. Convert plasminogen to plasmin D. Inhibit the conversion of fibrin to fibrinogen

A. Competitive inhibition of plasminogen activation

Which of the following is defined as pathological formation of a 'hemostatic plug' within the vasculature in the absence of bleeding? A. Aggregation B. Hemostasis C. Hypercoagulability D. Thrombosis

D. Thrombosis