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Big Pharma > Important Info 2.1/2.0 ex 2 > Flashcards

Important Info 2.1/2.0 ex 2 Flashcards

1
Q

Older patients over age of 65

A

phase 1

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2
Q

What are the 3 endogenous catecholamine

A

dopamine, NE, and EPI

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3
Q

Cardiac output

A

SV and HR

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4
Q

Which med increases cardiac contraction to by stimulating myocardial B1 receptors

A

DOBUTamine

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5
Q

Which of following agents inhibits PDE3 inhibitor

A

milrinone

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6
Q

Which of following is preferred for method for anaphylaxis

A

intermuscular

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7
Q

Minimize potential for adverse effects dry mouth

A

M3

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8
Q

What are following statements for pharmacodynamic

A

sedation from blocking histamine 1 receptors

????

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9
Q

Gingival hyperplasia

A

diltiazem

less common but still true

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10
Q

Which of following is true regarding B2 adrenergic receptors

A

bronchodilation

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11
Q

What anti-anginal med and TdP

A

Ranolazine

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12
Q

Which of the following anticholinergic drugs is considered a quaternary amine

A

glycopyrrolate

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13
Q

Alpha 1 Agonist and nasal decongestion

A

phenylephrine

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14
Q

Ventricular repolarization

A

T wave

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15
Q

Toxin induced cell damage from drug metabolite can occur through a series of non-covalent

A

formation of hydrogen peroxide

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16
Q

A drug that has an effect of increasing gastric emptying

A

increased absorption

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17
Q

What is a common pharmacological effect of alpha adrenergic antagonists that can occur if a dental patient gets up from chair too quickly

A

alpha 1 blockade - HYPOtension

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18
Q

Which medication is an example of a selective B2 agonist that provides short term control in patients with asthma

A

albuterol

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19
Q

Gingival hyperplasia is a side effect with seizures

A

phenytoin (Dilantin)

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20
Q

Which of the following results from covalent modification and alteration of DNA

A

mutagenesis

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21
Q

An example of an adverse effect that is independent of the drugs main pharmacological mechanism of action is which of the following

A

aspirin and tinnitus

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22
Q

Which of the following medications has a possible adverse drug reaction of photo sensitivity which may make it painful for patients to have a dental light in their eyes

A

amiodarone

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23
Q

Medication increase contractility by inhibiting PD3

A

Milrinone

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24
Q

Anti epileptic meds controlled substance

A

Phenylbarbitol

not sure if we learned this

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25
Q
A
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26
Q

Hydros side effect

A

Constipation

no idea what this is talking about

27
Q

Which anti depressant bruxism?

A

Fluoxetine

Not sure where this is in the slides

28
Q

Definition of adrenergic fiber

A

Release norepinephrine

29
Q

Potassium channel blockers which von Williams class for anti-arrhythmic meds?

30
Q

Which nervous system is considered “all or nothing” meaning it fires at once, on-or-off?

A

somatic

pretty sure its sympathetic ??

31
Q

Pt comes to clinic to extract wisdom teeth. 24 wks pregnant. Taking folic acid 1 mg daily and lithium carbonate 600 mg 3x daily for bipolar. Because lithium is readily eliminated, what effect can you expect pregnancy to have on JR’s lithium drug level?

A

Decreased Lithium

32
Q

Variation in drug response may result from different drug concentration at sites of drug action or by different response to same drug concentration.

33
Q

Ca and Vit D supplementation is recommended for pt taking which ONE of the following antiepileptic meds?

A

Zonisamide (Zonegran)

don’t think we learned this?

34
Q

Which ion is required to bind to actin and myosin to produce cardiac contractility?

35
Q

Herbal product recommended in tx guidelines for depression?

A

st john wort

don’t know if we learned this

36
Q

Sympathetic post ganglionic?

A

Norepinephrine

36
Q

Beta blockers considered safest for use in pt with severe asthma?

A

Metoprolol

37
Q

Enzymes required for breaking down acetylcholine in serum?

A

Acetylcholinesterase

38
Q

Grapefruit juice known to be an inhibitor of which specific liver enzyme?

39
Q

Type of arrhythmia with HR greater than 100 BPM?

A

Tachycardia

40
Q

Ethnic variation possible contributor to responses individuals experience to meds and other drugs. Example- Chinese descent do not metabolize alcohol as well- experience flushing palpitations. Due to build up of plasma concentrations of

A

Acetaldehyde

41
Q

Characteristic of alpha 1 adrenergic receptor activation?

A

Increases sympathetic tone

42
Q

Pt with severe cholinergic toxicity, which symptoms would atropine NOT be effective in treating?

43
Q

Good surrogate marker of myocardial oxygen demand (MVO2)?

A

Double product (HR x systolic BP)

44
Q

Ca channel blockers are in which Vaugh-Williams classification for antiarrhythmic meds?

45
Q

Agents considered first-line treatment to INC HR and to dry secretions in pt exposed to nerve agents (VX nerve gas)?

46
Q

Released by adrenal medulla and considered neurohormone?

A

Epinephrine

47
Q

Fluoxetine is SSRI antidepressant and inhibits Cytochorme P450 2D6. Risperidone is antipsychotic and is substrate for P450 2D6. What effect would you expect fluoxetine to have on risperidone in terms of drug concentration?

A

Risperidone levels increase

48
Q

Beta 1 receptor agonism leads to all of the following except

A

Bronchodilation

49
Q

NT blockers classified as depolarizing paralytic?

A

Succinylcholine

50
Q

NT released POST ganglionic fibers of parasympathetic?

A

Acetylcholine

51
Q

During dental procedure, which drugs should you avoid in pt who has asthma?

A

All of the above- aspirin, opiates, antihistamine

52
Q

Meds most likely to be associated with development of anaphylactic shock?

A

Penicillin

53
Q

Physical state of pregnancy can contribute to drug variation. Correct observation of
physiologic change that commonly occurs during pregnancy?

A

INC renal blood flow and GFR

54
Q

Symptoms would you NOT expect to see in pt presenting with acute cholinergic toxicity?

55
Q

Meds improves angina by inhibiting Ca ions influx thru L type or “slow” Ca channels?

A

Amlodipine (Norvasc)

56
Q

Beta-adernoreceptor blockers (Beta blockers) are which vaugh williams classification for
antiarrhythmic meds?

57
Q

Routine cleaning. Complains of dry mouth and feeling sleepy. Meds most likely to result in dry mouth and sedation due to its pharmacodynamic based receptor effects at
histamine receptor?

A

Diphenhydramine (Benadryl) an allergy med

58
Q

Irreversible indirect acting cholinergic agent?

59
Q

Regenerate acetylcholinesterase following exposure to nerve agents?

A

Pralidoxime

60
Q

Ion responsible for rapid repolarization of the cardiac action potential?

61
Q

Greatest risk of causing orthostatic hypotension?

62
Q

Pt utilizing beta agonist albuterol. Which of following meds Is most likely to result in
interaction and negate beneficial effect of albuterol?

A

Propranolol

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