Important Info 2.1/2.0 ex 2

Question 1

Older patients over age of 65

Answer 1

phase 1

Question 2

What are the 3 endogenous catecholamine

Answer 2

dopamine, NE, and EPI

Question 3

Cardiac output

Answer 3

SV and HR

Question 4

Which med increases cardiac contraction to by stimulating myocardial B1 receptors

Answer 4

DOBUTamine

Question 5

Which of following agents inhibits PDE3 inhibitor

Answer 5

milrinone

Question 6

Which of following is preferred for method for anaphylaxis

Answer 6

intermuscular

Question 7

Minimize potential for adverse effects dry mouth

Answer 7

M3

Question 8

What are following statements for pharmacodynamic

Answer 8

sedation from blocking histamine 1 receptors

????

Question 9

Gingival hyperplasia

Answer 9

diltiazem

less common but still true

Question 10

Which of following is true regarding B2 adrenergic receptors

Answer 10

bronchodilation

Question 11

What anti-anginal med and TdP

Answer 11

Ranolazine

Question 12

Which of the following anticholinergic drugs is considered a quaternary amine

Answer 12

glycopyrrolate

Question 13

Alpha 1 Agonist and nasal decongestion

Answer 13

phenylephrine

Question 14

Ventricular repolarization

Answer 14

T wave

Question 15

Toxin induced cell damage from drug metabolite can occur through a series of non-covalent

Answer 15

formation of hydrogen peroxide

Question 16

A drug that has an effect of increasing gastric emptying

Answer 16

increased absorption

Question 17

What is a common pharmacological effect of alpha adrenergic antagonists that can occur if a dental patient gets up from chair too quickly

Answer 17

alpha 1 blockade - HYPOtension

Question 18

Which medication is an example of a selective B2 agonist that provides short term control in patients with asthma

Answer 18

albuterol

Question 19

Gingival hyperplasia is a side effect with seizures

Answer 19

phenytoin (Dilantin)

Question 20

Which of the following results from covalent modification and alteration of DNA

Answer 20

mutagenesis

Question 21

An example of an adverse effect that is independent of the drugs main pharmacological mechanism of action is which of the following

Answer 21

aspirin and tinnitus

Question 22

Which of the following medications has a possible adverse drug reaction of photo sensitivity which may make it painful for patients to have a dental light in their eyes

Answer 22

amiodarone

Question 23

Medication increase contractility by inhibiting PD3

Answer 23

Milrinone

Question 24

Anti epileptic meds controlled substance

Answer 24

Phenylbarbitol

not sure if we learned this

Question 26

Hydros side effect

Answer 26

Constipation | no idea what this is talking about

Question 27

Which anti depressant bruxism?

Answer 27

Fluoxetine | Not sure where this is in the slides

Question 28

Definition of adrenergic fiber

Answer 28

Release norepinephrine

Question 29

Potassium channel blockers which von Williams class for anti-arrhythmic meds?

Answer 29

Class 3

Question 30

Which nervous system is considered “all or nothing” meaning it fires at once, on-or-off?

Answer 30

somatic ## Footnote pretty sure its sympathetic ??

Question 31

Pt comes to clinic to extract wisdom teeth. 24 wks pregnant. Taking folic acid 1 mg daily and lithium carbonate 600 mg 3x daily for bipolar. Because lithium is readily eliminated, what effect can you expect pregnancy to have on JR’s lithium drug level?

Answer 31

Decreased Lithium

Question 32

Variation in drug response may result from different drug concentration at sites of drug action or by different response to same drug concentration.

Answer 32

True

Question 33

Ca and Vit D supplementation is recommended for pt taking which ONE of the following antiepileptic meds?

Answer 33

Zonisamide (Zonegran) | don't think we learned this?

Question 34

Which ion is required to bind to actin and myosin to produce cardiac contractility?

Answer 34

calcium

Question 35

Herbal product recommended in tx guidelines for depression?

Answer 35

st john wort | don't know if we learned this

Question 36

Sympathetic post ganglionic?

Answer 36

Norepinephrine

Question 36

Beta blockers considered safest for use in pt with severe asthma?

Answer 36

Metoprolol

Question 37

Enzymes required for breaking down acetylcholine in serum?

Answer 37

Acetylcholinesterase

Question 38

Grapefruit juice known to be an inhibitor of which specific liver enzyme?

Answer 38

CYP3A4

Question 39

Type of arrhythmia with HR greater than 100 BPM?

Answer 39

Tachycardia

Question 40

Ethnic variation possible contributor to responses individuals experience to meds and other drugs. Example- Chinese descent do not metabolize alcohol as well- experience flushing palpitations. Due to build up of plasma concentrations of

Answer 40

Acetaldehyde

Question 41

Characteristic of alpha 1 adrenergic receptor activation?

Answer 41

Increases sympathetic tone

Question 42

Pt with severe cholinergic toxicity, which symptoms would atropine NOT be effective in treating?

Answer 42

Paralysis

Question 43

Good surrogate marker of myocardial oxygen demand (MVO2)?

Answer 43

Double product (HR x systolic BP)

Question 44

Ca channel blockers are in which Vaugh-Williams classification for antiarrhythmic meds?

Answer 44

Class 4

Question 45

Agents considered first-line treatment to INC HR and to dry secretions in pt exposed to nerve agents (VX nerve gas)?

Answer 45

Atropine

Question 46

Released by adrenal medulla and considered neurohormone?

Answer 46

Epinephrine

Question 47

Fluoxetine is SSRI antidepressant and inhibits Cytochorme P450 2D6. Risperidone is antipsychotic and is substrate for P450 2D6. What effect would you expect fluoxetine to have on risperidone in terms of drug concentration?

Answer 47

Risperidone levels increase

Question 48

Beta 1 receptor agonism leads to all of the following except

Answer 48

Bronchodilation

Question 49

NT blockers classified as depolarizing paralytic?

Answer 49

Succinylcholine

Question 50

NT released POST ganglionic fibers of parasympathetic?

Answer 50

Acetylcholine

Question 51

During dental procedure, which drugs should you avoid in pt who has asthma?

Answer 51

All of the above- aspirin, opiates, antihistamine

Question 52

Meds most likely to be associated with development of anaphylactic shock?

Answer 52

Penicillin

Question 53

Physical state of pregnancy can contribute to drug variation. Correct observation of physiologic change that commonly occurs during pregnancy?

Answer 53

INC renal blood flow and GFR

Question 54

Symptoms would you NOT expect to see in pt presenting with acute cholinergic toxicity?

Answer 54

dry mouth

Question 55

Meds improves angina by inhibiting Ca ions influx thru L type or “slow” Ca channels?

Answer 55

Amlodipine (Norvasc)

Question 56

Beta-adernoreceptor blockers (Beta blockers) are which vaugh williams classification for antiarrhythmic meds?

Answer 56

Class 2

Question 57

Routine cleaning. Complains of dry mouth and feeling sleepy. Meds most likely to result in dry mouth and sedation due to its pharmacodynamic based receptor effects at histamine receptor?

Answer 57

Diphenhydramine (Benadryl) an allergy med

Question 58

Irreversible indirect acting cholinergic agent?

Answer 58

sarin

Question 59

Regenerate acetylcholinesterase following exposure to nerve agents?

Answer 59

Pralidoxime

Question 60

Ion responsible for rapid repolarization of the cardiac action potential?

Answer 60

Potassium

Question 61

Greatest risk of causing orthostatic hypotension?

Answer 61

Terazosin

Question 62

Pt utilizing beta agonist albuterol. Which of following meds Is most likely to result in interaction and negate beneficial effect of albuterol?

Answer 62

Propranolol