Important Info Exam 1 2.3 Flashcards
Study of drug effects at population level
Pharmacoepidemiology
Receptor that is involved with Jak-STAT pathway?
Cytokine
A drug that would be life saving with a patient with an overdose. This will help them with breathing…
Naloxone
Receptor found inside cytoplasm would be bound to
Heat shock protein
8 years
idk what this means
What act allows drug to be given to humans before Phase I
a. Investing New Drug Act (IND)
b. New Drug Act
a. Investing New Drug Act (IND)
DSHEA does NOT
a. Children
b. Diet
c. Substance intended for use in diagnosis, mitigation
c. Substance intended for use in diagnosis, mitigation
Paul Ehrilich is the Father of Modern Chemotherapy. He argued that drug actions not result of magical “vital forces.” A drug will not work unless it is ____
Bound
Enzymes that make the best targets for drug action are those that:
Catalyze rate-limiting steps in synthesis of key molecules
Upon binding agonist, insulin receptors form homodimers that phosphorylate intracellular proteins at sites containing:
Tyrosine
Allow agonist binds to same site as receptor
a. Competitive antagonist
b. Allosteric agonist
c. Allosteric antagonists
a. Competitive antagonist
i dont think this is correct- haley
i agree. it is c - molly
What needs to happen to cross the placental border?
High lipophilicity
G protein diversity of effects
Heterogeneity of g-proteins
Which of the following drugs would most likely need a loading dose to help reach therapeutic levels?
Colchicine (t1/2 = 30hr)
Following the agonist activation of a single G-Protein Coupled Receptor, amplification of
downstream signal occurs because:
Duration of activation of GTP bound G-Protein is longer than agonist activation of receptor
The drug-receptor bonds that would most likely lead to irreversible drug-receptor interaction are:
Covalent bonds
What determines the degree of movement of a drug between body compartments?
a. Partition constant
b. Degree of ionization
c. pH
d. Size
e. All of the above
e. All of the above
Aspirin readily donates a proton in aqueous solutions and pyrimethamine readily
accepts a protein in aqueous solution. Thus, aspirin is a and pyrimethamine is a
Acid; Base
What happens to the dose-response curve for an agonist when increasing concentration
of a competitive antagonist are added?
Shifts to the right
What drug will competitively inhibit the rate limiting step in cholesterol synthesis
Lovastatin
What is the best drug for lowering concentrations of circulating plasma proteins
Infliximab
Most drugs are either ____ acids or _____ bases.
Weak; Weak
The lipid soluble form of an acid is and the lipid-soluble form of a base is
protonated, unprotonated
bioavailability of IV
100%
first pass effect organ
liver
which of the following would receive a drug slowly?
Adipose
Acidic drugs bind primarily to which of the following plasma proteins?
albumin
Basic drugs bind primarily to which of the following plasma proteins?
alpha glycoprotein
Which of the following can produce a systemic and therapeutic response? A drug that is:
a. Bound to plasma albumin
b. Concentrated in the bile
c. Not absorbed from the GI tract
d. unbound to plasma proteins
d. unbound to plasma proteins
If a drug 80% bound to blood elements or plasma proteins, what part is considered the
free form?
20%
Warfarin (Coumadin) is a CYP-450 2C9 substrate and sulfamethoxole/trimethoprim (Bactrim) is a 2C9 inhibitor. Which of the following effects would be expected if the drugs were co-administered?
Increased warfarin effect
Pharmacokinectics is the effect of the _____ and pharmacodynamics is the effect of the ______
Body on the drug; Drug on the body
Which of the following is NOT a pharmacokinetic process?
Adverse effects
Which of the following is NOT a pharmacokinetic process?
a. Alteration of the drug by hepatic enzymes
b. Urinary excretion of inactive drug metabolites
c. Deposition of lipophilic drug in adipose tissue
d. Drug induced dilation of coronary and peripheral vasculature
d. Drug induced dilation of coronary and peripheral vasculature
body’s “tank”
volume of distribution
For first-order drug elimination, half-life t(1/2) is at two places on the curve and a constant is lost per unit time.
Equal, percentage
heat shock protein bound receptors
steroid (androgen)
drug that inhibits cholesterol synthesis by inhibiting rate limiting step
lovastatin
What describes the movement of a drug between blood and tissues?
a. Absorption
b. Metabolism
c. Distribution
d. Excretion
c. Distribution
7 transmembrane spanning domain
G- protein
Which of the following is effective
A drug that is unbound to protein
Which are non-ionized and pass membranes more readily?
Protonated weak acids and non-protonated weak bases
A target concentration of 7.5 mg/mL of theophylline is required for a 60 kg patient.
What is appropriate equation to determine the IV loading dose given the following: Vd =
0.5L/kg, Cl = 0.04 L/kg/hr, t1/2 = 9.3hr
D = (Vd x Css) / F
Which of the following best describes minimal effective concentration (MEC)?
a. The minimal drug plasma concentration that can be detected
b. The minimal drug plasma concentration to enter tissues
c. The minimal drug plasma concentration to elicit an effect
d. The minimal drug plasma concentration to reach therapeutic levels
c. The minimal drug plasma concentration to elicit an effect
Physiochemical properties of drug that allow it to bind to multiple things
Chirality (stereoisomers)
