Important Info Exam 1 2.1 Flashcards
Which of the following has the slowest perfusion?
a. Brain
b. Fat
b. Fat
Which will most readily dissolve acidic drugs
A-1 acid glycoprotein
idk about this one… -haley
this has to be opposite - molly
Which will most readily dissolve basic drugs
Albumin
idk about this one… -haley
this has to be opposite - molly
What did DSHEA do?
Made it so supplements aren’t regulated by FDA
What is protein molecule which function to recognize and respond to endogenous chemical signals and defined by it’s ligand
Receptor
Put these in order of the fastest acting: androgen, histamine, insulin
histamine
insulin
androgen
?
Why does histamine do so many things?
Heterogeneity of the G protein coupled receptors
Which of the following has 7 transmembade spanning domain
Histamine 1 receptor
Which of the following only has 1 transmembrane spanning domain?
Kinase-Linked & Related Receptors
(insulin)
Insulin activates
- activates PI3 kinase pathway
» turns on or off gene expression
» activates glycogen synthesis - activates Mitogen Activated Protein (MAP) Kinase pathway
» turns on or off gene expression
?
Pharmacokinectics is the ___________ ,pharmacodynamics is how the
_____________
Action of the body on the drug, drug on the body
Definition of a drug
Substance intended for use in diagnosis, mitigation,
Generic drug definition
Has the same quality, performance and intended use
All of the following are pharmykinetics except
Adverse effects
Study of genetic influences on the responses of drugs
Pharmacogenomics
Study of cost benefit detrements of drugs
Pharmacoeconomics
Which of the following is effective
A drug that is unbound to protein
Which of the following is more fat soluble and is trapped in lipophilic components
Neutral acid/base
Which are non-ionized and pass membranes more readily?
Protonated weak acids and non-protonated weak bases
Something that readily donates a proton is ______________ and something that
readily receives a proton is _____________
Acid, base
A patent is generally good for how long after the drug is on the market
5-10 years
What is the best drug for circulating plasma proteins
Monoclonal antibodies
All of the following are receptors except
Some weird thing
This receptor in the cytoplasm
Steroid/androgen
Which binds irreversibly
Covalent
Testosterone will do what?
Go to the nucleus to change transcription
Physiochemical properties of drugs that allow it to bind to multiple things
Chirality, stereoisomers…blah blah blah
What makes HMG-CoA reductase a good thing to be to be bound to?
Because it goes to the rate limiting step
Competitive inhibitor will do what to the dose response curve?
Shift to the right
COmpetetive antagonist will do what to the E50?
Shift to the right
This drug will inhibit the rate limiting step and stop cholesterol synthesis
Lovastatin
Which will most likely allow an agonist to bind normally
Allosteric agonist
In first pass metabolism, this organ does most of the metabolism
Liver
What makes downstream effects last so long in G-protein
Cascaded downstream signal lasts longer than agonist binding
Which receptor has a ligand binding site inside the cell
Steroid receptor
Acetylcholine is
Ligand gated ion channel
Bactrim is a 2C9 inhibitor and warfarin is the substrate for 2C9. What will
happen in someone who takes Bactrim?
Warfarin will be enhanced
Which of the following best describes MEC?
Lowest amount to be effective
Which describes the amount given over the amount absorbed
Bioavailability
How would you best excrete acid?
Alkyline urine
Bioavailability of IV is assumed to be
100%
First order kinetics will have ______________ over time
Equal time, equal percentage
Which one refers to your body’s “tank”
Volume of distribution
Which of these would you have more of a loading dose
a. Something that takes 30 days
b. Something that takes 10 seconds
a. Something that takes 30 days
