Important Info Exam 1 2.1

Question 1

Which of the following has the slowest perfusion?
a. Brain
b. Fat

Answer 1

b. Fat

Question 2

Which will most readily dissolve acidic drugs

Answer 2

A-1 acid glycoprotein

idk about this one… -haley
this has to be opposite - molly

Question 3

Which will most readily dissolve basic drugs

Answer 3

Albumin

idk about this one… -haley
this has to be opposite - molly

Question 4

What did DSHEA do?

Answer 4

Made it so supplements aren’t regulated by FDA

Question 5

What is protein molecule which function to recognize and respond to endogenous chemical signals and defined by it’s ligand

Answer 5

Receptor

Question 6

Put these in order of the fastest acting: androgen, histamine, insulin

Answer 6

histamine
insulin
androgen

?

Question 7

Why does histamine do so many things?

Answer 7

Heterogeneity of the G protein coupled receptors

Question 8

Which of the following has 7 transmembade spanning domain

Answer 8

Histamine 1 receptor

Question 9

Which of the following only has 1 transmembrane spanning domain?

Answer 9

Kinase-Linked & Related Receptors
(insulin)

Question 10

Insulin activates

Answer 10

• activates PI3 kinase pathway
  » turns on or off gene expression
  » activates glycogen synthesis
• activates Mitogen Activated Protein (MAP) Kinase pathway
  » turns on or off gene expression

?

Question 11

Pharmacokinectics is the ___________ ,pharmacodynamics is how the
_____________

Answer 11

Action of the body on the drug, drug on the body

Question 12

Definition of a drug

Answer 12

Substance intended for use in diagnosis, mitigation,

Question 13

Generic drug definition

Answer 13

Has the same quality, performance and intended use

Question 14

All of the following are pharmykinetics except

Answer 14

Adverse effects

Question 15

Study of genetic influences on the responses of drugs

Answer 15

Pharmacogenomics

Question 16

Study of cost benefit detrements of drugs

Answer 16

Pharmacoeconomics

Question 17

Which of the following is effective

Answer 17

A drug that is unbound to protein

Question 18

Which of the following is more fat soluble and is trapped in lipophilic components

Answer 18

Neutral acid/base

Question 19

Which are non-ionized and pass membranes more readily?

Answer 19

Protonated weak acids and non-protonated weak bases

Question 20

Something that readily donates a proton is ______________ and something that
readily receives a proton is _____________

Answer 20

Acid, base

Question 21

A patent is generally good for how long after the drug is on the market

Answer 21

5-10 years

Question 22

What is the best drug for circulating plasma proteins

Answer 22

Monoclonal antibodies

Question 23

All of the following are receptors except

Answer 23

Some weird thing

Question 24

This receptor in the cytoplasm

Answer 24

Steroid/androgen

Question 25

Which binds irreversibly

Answer 25

Covalent

Question 26

Testosterone will do what?

Answer 26

Go to the nucleus to change transcription

Question 27

Physiochemical properties of drugs that allow it to bind to multiple things

Answer 27

Chirality, stereoisomers...blah blah blah

Question 28

What makes HMG-CoA reductase a good thing to be to be bound to?

Answer 28

Because it goes to the rate limiting step

Question 29

Competitive inhibitor will do what to the dose response curve?

Answer 29

Shift to the right

Question 30

COmpetetive antagonist will do what to the E50?

Answer 30

Shift to the right

Question 31

This drug will inhibit the rate limiting step and stop cholesterol synthesis

Answer 31

Lovastatin

Question 32

Which will most likely allow an agonist to bind normally

Answer 32

Allosteric agonist

Question 33

In first pass metabolism, this organ does most of the metabolism

Answer 33

Liver

Question 34

What makes downstream effects last so long in G-protein

Answer 34

Cascaded downstream signal lasts longer than agonist binding

Question 35

Which receptor has a ligand binding site inside the cell

Answer 35

Steroid receptor

Question 36

Acetylcholine is

Answer 36

Ligand gated ion channel

Question 37

Bactrim is a 2C9 inhibitor and warfarin is the substrate for 2C9. What will happen in someone who takes Bactrim?

Answer 37

Warfarin will be enhanced

Question 38

Which of the following best describes MEC?

Answer 38

Lowest amount to be effective

Question 39

Which describes the amount given over the amount absorbed

Answer 39

Bioavailability

Question 40

How would you best excrete acid?

Answer 40

Alkyline urine

Question 41

Bioavailability of IV is assumed to be

Answer 41

100%

Question 42

First order kinetics will have ______________ over time

Answer 42

Equal time, equal percentage

Question 43

Which one refers to your body’s “tank”

Answer 43

Volume of distribution

Question 44

Which of these would you have more of a loading dose a. Something that takes 30 days b. Something that takes 10 seconds

Answer 44

a. Something that takes 30 days