Important Info 2.2 ex 2 Flashcards
Which of the following is a symptom of acute cholinergic toxicity?
Bradycardia
A drug that has an effect of increasing gastric emptying:
Increased absorption
What ions are associated with phase 0?
Sodium
What of the following medications has a high risk of QT prolongation and TDP?
All of the above (two of the options were dofetilide and dronedarone; didn’t recognize last option)
all class III antiarrythmic meds:
- amiodarone
- dofetilide
- dronedarone
- sotalol
- ibutilide
plus ranolazine
Which of the following is an “irreversible” indirect cholinergic agent?
Novichok
other correct option:
- parathion
- malathion
- sarin
- soman
- tabun
- VX
Which of the following is an arrythmia that results in a HR of less than 60 bpm?
Bradycardia
What Vaughn-Williams Classification for Ca channel blockers
Vaughn-Williams Classification IV
Which receptor minimizes the potential for dry mouth?
M3
Which is a neurohormone?
Epinephrine
Which of the following drugs causes dry mouth/urinary hesitancy?
Disopyramide (Norpace)
Which of the following medications is likely to result in dry mouth and sedation due to its effects at the histamine receptor?
Diphenhydramine (Benadryl) an allergy medication
Which medication increases cardiac contractility by inhibiting PDE3?
Milrinone
Which one of the following medications undergoes a pharmacodynamic interaction and negates the beneficial effect of albuterol?
Propranolol (Inderal) a beta blocker
Which of the following is beta 1 specific?
Metoprolol
Which of the following is the best beta blocker for asthma patients?
Metoprolol
Which one of the following is considered a non-covalent type of interaction?
Formation of hydrogen peroxide
Which of the following medications has a risk of gingival hyperplasia?
Verapamil
Which of the following is most commonly associated with gingival hyperplasia?
Phenytoin (dilantin)
Post-ganglionic sympathetic releases:
NE
Post-ganglionic parasympathetic releases:
Ach
Autonomic pre-ganglionic releases
Ach
Regeneration of AchE
Pralidoxime
First line treatment for patient exposed to nerve gas
Pralidoxime (nah)
- it’s atropine
What do you give to a patient with anaphylaxis?
0.3 mg IM epinephrine
Short acting beta 2 agonist in asthmatic patients
Albuterol
Which drug metabolism phase functions impair with age?
Phase 1
Blocks calcium from entering type L channels
Nifedipine
What contributes to cardiac output?
Stroke volume and heart rate
Which ion is required to bind actin and myosin to produce cardiac contractility?
Calcium
Which drug inhibits the Na/K ATPase?
Digoxin
Which commonly occurs during pregnancy?
Increased renal blood flow and GFR
Which increases cardiac contraction by stimulating myocardial B1 receptors?
DOBUTamine
Which is a short-term temporizing agent for hypotension and also serves as a nasal decongestant?
Phenylephrine
What are the three endogenous catecholamines?
Dopamine, NE, and epinephrine
Myocardial oxygen demand is determined by
HR and myocardial contractility
Characteristic of alpha 1 adrenergic receptor activation?
Increased sympathetic tone
Which of the following results from covalent modification and alteration of DNA?
Mutagenesis
Adverse effect independent of drugs main mechanism
Aspirin and tinnitus
Meds most likely to be associated with development of anaphylactic shock?
Penicillin
Example of pharmacodynamics
Constipated from Ach block
Which of the following drugs has the greatest risk of causing orthostatic hypotension?
Terazosin
Ethnic variation…that some individuals of Chinese…this is because of increased concentrations of
Acetaldehyde
Acetylcholine is broken down by which of the following enzymes?
Acetylcholinesterase
Which of the following does beta 1 NOT do?
Bronchodilation
Fluoxetine is SSRI antidepressant and inhibits Cytochrome P450 2D6. Risperidone is antipsychotic and is substrate for P450 2D6. What effect would you expect fluoxetine to have on risperidone in terms of drug concentration?
Risperidone levels increase (he used different drug examples)
Atrial depolarization
= P wave
Which of the following is a depolarizing neuromuscular blocker?
Succinylcholine
What tertiary amine …. something something (all but 1 option were quaternary)
Atropine
A drug that treated cholinergic toxicity would NOT treat:
Paralysis
Prozac inhibits which liver enzyme?
2D6
Which type of blockade can cause a patient…if they go from supine immediately standing? (or something like this)
Alpha 1 blockade; orthostatic hypotension
Which drugs are contraindicated in patients with asthma?
All of the above (opiates, aspirin, antihistamines)
