Important Info Exam 1 2.4 Flashcards
Which of the following is NOT an action of the body on a drug?
a. Absorption
b. Distribution
c. Metabolism
d. Excretion
e. Adverse effects
e. Adverse effects
The study of cost and benefits/detriments of drugs used clinically.
Pharmacoeconomics
The study of drugs effects between individuals in a population and between populations
Pharmacoepidemiology
What phase can be used for humans but still is in the post-marketing surveillance phase?
Phase 4
What phase is the investigative new drug phase?
After preclinical testing and before phase 1.
Which of these drug: target interactions is an example of covalent bonding
(irreversible)?
a. Aspirin and cyclooxygenase
b. Opiod and mu receptors
c. Inflimaxib and HMG-CoA reductase
a. Aspirin and cyclooxygenase
What determines the degree of movement of a drug between body compartment?
a. Size
b. pH
c. degree of ionization
d. protein binding
e. all of the above
e. all of the above
Aspirin readily donates a proton in aqueous solutions and pyrimethamine readily
accepts a protein in aqueous solution. Thus, aspirin is a ___ and pyrimethamine is a
____.
Acid; base
For a dose/response chart, what will you need to do the dose if you add a competitive
inhibitor.
Increase dose to get effect
Following the agonist activation of a single GPCR, amplification of the downstream signal occurs because
Duration of activation of G-protein is longer than agonist activation of receptor
What allows histamine to get a variety of different effects in different receptors?
Heterogeneity of the g-protein coupled receptors
What superfamily has a DNA binding domain?
Nuclear receptors
What keeps the nuclear receptors ligands stable?
Heat shock protein
What receptor takes the longest and requires hours to days for an effect?
a. G-coupled protein receptor
b. Ligand gated receptor
c. Nuclear receptor
d. Kinase-linked receptor
c. Nuclear receptor
Acidic drugs bind primarily to which of the following plasma proteins?
Albumin
Basic drugs bind primarily to which of the following plasma proteins?
Alpha-1 glycoprotein
Question for therapeutic response (two questions about this, worded differently)
Unbound to plasma proteins
If a drug is 80% bound to blood elements or plasma proteins, what part is considered
the free form?
20%
What is the average bioavailability of a drug following IV administration?
100%
What organ is responsible for metabolism in the first pass effect?
liver
Which of the following would receive a drug slowly?
adipose
Bactrim is a 2C9 inhibitor and warfarin is the substrate for 2C9. What will happen in
someone who takes Bactrim?
a. Warfarin will be enhanced
b. Warfarin will decrease
c. Sulfamethoxazole/trimethoprim will be enhanced
d. Sulfamethoxazole/trimethoprim will decrease
a. Warfarin will be enhanced
Pharmacokinetics is the effect of the ____, and pharmacodynamics is the effect of the
_____
Body on the drug; drug on the body
Which of the following is NOT a pharmacokinetic process?
The drug causes dilation of coronary vessels
