Important Info Exam 1 2.0

Question 1

A patent is generally good for how long after the drug is on the market?

Answer 1

5-10 years

Question 2

Protein molecules which function to recognize and response to endogenous chemical signals and are classified based upon the ligands that bind them are called:
1. Ion channels
2. Enzymes
3. Receptors
4. Carrier molecules

Answer 2

3. Receptors

Question 3

Physiochemical properties of drug that allow it to bind to multiple things

Answer 3

Chirality (stereoisomers)

Question 4

Adrenergic receptor antagonists are used as ____ and exhibit chirality.

Answer 4

Racemic mixtures

Question 5

Put these receptors in order of the fastest acting
- Histamine receptor
- Nicotinic-ACh receptor
- Steroid receptor

Answer 5

Nicotinic-ACh receptor (fastest) > Histamine receptor > Steroid receptor

Question 6

Which of the following has 7 transmembrane spanning domains

Answer 6

Histamine 1 receptor (G-protein coupled)

or opioid receptor

Question 7

Which of the following only has 1 transmembrane spanning domain?

Answer 7

Insulin receptor (Kinase)

Question 8

Which receptor is found inside the cytoplasm and bound to heat shock protein?

Answer 8

Androgen receptors

AKA nuclear receptors; AKA steroid family receptors

Question 9

What drug will competitively inhibit the rate limiting step in cholesterol synthesis

Answer 9

Lovastatin

Question 10

What is the best drug for lowering concentrations of circulating plasma proteins

Answer 10

Monoclonal antibodies

Question 11

Which of the following is the amount of a drug absorbed per the amount administered?
1. Bioavailability
2. Bioequivalence
3. Drug absorption
4. Bioinequivalence
5. Dosage

Answer 11

1. Bioavailability

Question 12

Which of the following would receive a drug slowly?
1. Liver
2. Brain
3. Fat
4. Muscle
5. Kidney

Answer 12

3. Fat

Question 13

Bactrim is a 2C9 inhibitor and warfarin is the substrate for 2C9. What will happen in someone who takes Bactrim?

Answer 13

Warfarin will be enhanced and there will be an increase of side effects

Question 14

In zero order kinetics, it is a ___- ___ ____ in which ___ occurs. What happens to half life.

Answer 14

rate-limited process , saturation occurs, half life decreases over time with decreasing concentration.

Question 15

A loading dose is needed for drugs with (shorter or longer) half lives?

Answer 15

longer since it will take longer to reach plateau phase.