Important Info Exam 1 1.9 Flashcards
The genetic study of absorption, distribution, metabolism, excretion and receptor interaction is termed as
Pharmacogenetics
The DSHEA determined that
The FDSA is not allowed to review supplements and botanicals as drugs
The FDA defines a drug as
A substance used in the diagnosis, cure, mitigation, treatment or prevention of a disease
The drug must be fully ionized to be effectively released from the body
True
or false? (i think its true?- haley)
google says being ionized helps but isn’t necessarily required… so imma go with true - molly
By the time that a patent gets released to the public, how much time is left?
5-10 years
For every drug developed, how many attempted drugs are typically made?
1,000
What is termed as a protein molecule which functions to recognize and respond to endogenous chemical signals?
Receptor
Which one is most likely to be an irreversible bond?
Covalent
If a drug is ionized it readily crosses the plasma membrane.
False
Patient overdosed on aspirin. What is the best course of treatment?
Alkalize the urine
A drug is able to bind to a lot of things because of
Chirality
What kind of drug is most likely to bind to a site other than the active site of a receptor?
Allosteric antagonist
When a competitive antagonist binds to a receptor what happens to the curve?
Shifts right
When a competitive antagonist binds to a receptor and affects to the E50 what happens?
Shifts right
What example from class is an example of a seven transmembrane domain?
Opioid receptor
One transmembrane spanning domain
Insulin receptor
Which receptor is found inside the cell at resting?
Steroid
What deals with heat shock proteins?
Steroid
After testosterone binds, what is the outcome?
Gene transcription
Once insulin receptor is bound to its receptor, what occurs?
Phosphorylation of tyrosine residues
Why is HMG-CoA effective?
It Targets the rate limiting step
What is an effective drug against cholesterol?
Lovastatin
What drug would be good at targeting circulating plasma proteins?
Monoclonal antibodies
An acidic drug in an acidic pH is
Non-ionized; protonated
A basic drug in a basic pH is
Non-ionized; deprotonated
Acids get trapped in ___ urine; bases get trapped in ___ urine why?
Alkaline; acidic
Amount of drug absorbed per the amount of drug administered
Bioavailability
When a drug is permanently eliminated from the body, what has occurred?
Clearance
The bioavailability of a drug that is given through IV is
100%
If a drug is 60% bound to protein, what is free in the blood?
40%
A drug has to be bound to be effective in the blood
False
What organ is involved in first pass? (intestines straight to liver)
Liver
What organ receives the most blood flow?
Kidney
What is subject to first pass out of the different ways drugs that can be given?
Oral
Which one is metabolized by a CP450?
Substrate
If we have a drug that is acting as an inhibitor and also have warfarin both put into the body, what is the outcome?
Increased warfarin effect
When there is a high Vd what is expected?
High lipophilicity
What is a zero order drug?
Phenotytoin
& warfarin, heparin, ethanol, high dose aspirin, and theophyline
Equation for half life
0.693/ke
What does MTC stand for?
Minimum toxic concentration
What is between MEC and MTC?
Therapeutic window
Exaggerated immunologic response to a drug is
Allergic response
A predicted response to a drug that is not part of the therapeutic effect is
Side effect
The body on the drug is ____, which the drug on the body is _____.
Kinetics; dynamics
Which one tracks drug movement through the body?
Kinetics
Which one is body on the drug?
Kinetics
Which one is the drug on the body?
Dynamics
An androgen receptor is an example of
Steroid receptor
The antagonist for opioids is
Naloxone
