Important Info Exam 1 1.9

Question 1

The genetic study of absorption, distribution, metabolism, excretion and receptor interaction is termed as

Answer 1

Pharmacogenetics

Question 2

The DSHEA determined that

Answer 2

The FDSA is not allowed to review supplements and botanicals as drugs

Question 3

The FDA defines a drug as

Answer 3

A substance used in the diagnosis, cure, mitigation, treatment or prevention of a disease

Question 4

The drug must be fully ionized to be effectively released from the body

Answer 4

True

or false? (i think its true?- haley)

google says being ionized helps but isn’t necessarily required… so imma go with true - molly

Question 5

By the time that a patent gets released to the public, how much time is left?

Answer 5

5-10 years

Question 6

For every drug developed, how many attempted drugs are typically made?

Answer 6

1,000

Question 7

What is termed as a protein molecule which functions to recognize and respond to endogenous chemical signals?

Answer 7

Receptor

Question 8

Which one is most likely to be an irreversible bond?

Answer 8

Covalent

Question 9

If a drug is ionized it readily crosses the plasma membrane.

Answer 9

False

Question 10

Patient overdosed on aspirin. What is the best course of treatment?

Answer 10

Alkalize the urine

Question 11

A drug is able to bind to a lot of things because of

Answer 11

Chirality

Question 12

What kind of drug is most likely to bind to a site other than the active site of a receptor?

Answer 12

Allosteric antagonist

Question 13

When a competitive antagonist binds to a receptor what happens to the curve?

Answer 13

Shifts right

Question 14

When a competitive antagonist binds to a receptor and affects to the E50 what happens?

Answer 14

Shifts right

Question 15

What example from class is an example of a seven transmembrane domain?

Answer 15

Opioid receptor

Question 16

One transmembrane spanning domain

Answer 16

Insulin receptor

Question 17

Which receptor is found inside the cell at resting?

Answer 17

Steroid

Question 18

What deals with heat shock proteins?

Answer 18

Steroid

Question 19

After testosterone binds, what is the outcome?

Answer 19

Gene transcription

Question 20

Once insulin receptor is bound to its receptor, what occurs?

Answer 20

Phosphorylation of tyrosine residues

Question 21

Why is HMG-CoA effective?

Answer 21

It Targets the rate limiting step

Question 22

What is an effective drug against cholesterol?

Answer 22

Lovastatin

Question 23

What drug would be good at targeting circulating plasma proteins?

Answer 23

Monoclonal antibodies

Question 24

An acidic drug in an acidic pH is

Answer 24

Non-ionized; protonated

Question 25

A basic drug in a basic pH is

Answer 25

Non-ionized; deprotonated

Question 26

Acids get trapped in ___ urine; bases get trapped in ___ urine why?

Answer 26

Alkaline; acidic

Question 27

Amount of drug absorbed per the amount of drug administered

Answer 27

Bioavailability

Question 28

When a drug is permanently eliminated from the body, what has occurred?

Answer 28

Clearance

Question 29

The bioavailability of a drug that is given through IV is

Answer 29

100%

Question 30

If a drug is 60% bound to protein, what is free in the blood?

Answer 30

40%

Question 31

A drug has to be bound to be effective in the blood

Answer 31

False

Question 32

What organ is involved in first pass? (intestines straight to liver)

Answer 32

Liver

Question 33

What organ receives the most blood flow?

Answer 33

Kidney

Question 34

What is subject to first pass out of the different ways drugs that can be given?

Answer 34

Oral

Question 35

Which one is metabolized by a CP450?

Answer 35

Substrate

Question 36

If we have a drug that is acting as an inhibitor and also have warfarin both put into the body, what is the outcome?

Answer 36

Increased warfarin effect

Question 37

When there is a high Vd what is expected?

Answer 37

High lipophilicity

Question 38

What is a zero order drug?

Answer 38

Phenotytoin | & warfarin, heparin, ethanol, high dose aspirin, and theophyline

Question 39

Equation for half life

Answer 39

0.693/ke

Question 40

What does MTC stand for?

Answer 40

Minimum toxic concentration

Question 41

What is between MEC and MTC?

Answer 41

Therapeutic window

Question 42

Exaggerated immunologic response to a drug is

Answer 42

Allergic response

Question 43

A predicted response to a drug that is not part of the therapeutic effect is

Answer 43

Side effect

Question 44

The body on the drug is ____, which the drug on the body is _____.

Answer 44

Kinetics; dynamics

Question 45

Which one tracks drug movement through the body?

Answer 45

Kinetics

Question 46

Which one is body on the drug?

Answer 46

Kinetics

Question 47

Which one is the drug on the body?

Answer 47

Dynamics

Question 48

An androgen receptor is an example of

Answer 48

Steroid receptor

Question 49

The antagonist for opioids is

Answer 49

Naloxone