Important Info 2.1 ex 2 Flashcards
Beta adrenoreceptor blocks (beta blockers) are in which Vaugh williams classification for antiarrhythmic medications?
a. Class I
b. Class II
c. Class III
d. Class IV
b. Class II
Which of the following substances is released by the adrenal medulla and is considered to be a neurohormone?
a. Epinephrine
b. Norepinephrine
c. Dopamine
d. Acetylcholine
a. Epinephrine
In older pt or those over the age of 65 years, it is not uncommon to see a decrease in hepatic activity, especially ______ metabolism which can lead to drug accumulation
a. Phase I
b. Phase 2
c. Phase 3
d. Phase 4
a. Phase I
Which antianginal medication has a risk of QT prolongation and may cause an arrhythmia called torsade de points (TdP)?
a. Atenolol
b. Isosorbide mononitrate
c. Ranolazine
d. Verapamil
c. Ranolazine
Beta 1 receptor agonism leads to all of the following except
a. increased HR
b. Bronchodilation
c. Positive inotropy
d. Increased conduction
b. Bronchodilation
Gingival hyperplasia is a side effect that has been associated MOST COMMONLY with which one of the following antiseizure medications?
a. Iamotrtigine
b. Topiramate
c. Phenytoin
d. Levetiracetam
c. Phenytoin
Cardiac output is a function of HR and other factor ?
a. Afterload
b. End diastolic volume
c. End systolic volume
d. Stroke volume
d. Stroke volume
Which of the following agents has the greatest risk causing orthostatic hypotension when your pt goes from sitting to standing
a. Tamsulosin
b. Clonidine
c. Dexmedetomidine
d. Terazosin
d. Terazosin
Which of the following agents is considered first line treatment to increase HR and to dry secretion in patients exposed to nerve agents, e.g. VX nerve gas?
a. Glycopyrrolate
b. Atropine
c. Edrophonium
d. Pralidoxime
b. Atropine
Which medication increased cardiac contractility by stimulating myocardial beta 1 receptors?
a. Digitoxin
b. DOBUTamin (Dobutrex)
c. Levosimendan
d. Milirinone
b. DOBUTamin (Dobutrex)
Which of the following is a good surrogate marker of myocardial oxygen demand (MVO2)?
a. Afterload
b. Double product (heart x systolic BP)
c. Preload
d. Troponin
b. Double product (heart x systolic BP)
A patient is utilizing the beta agonist albuterol (ventolin) on an as needed basis for asthma. Which on the following meds is most likely to result in a pharmacodynamic interaction and negate the beneficial effect of albuterol?
a. Propanolol
b. Ibuprofen, NSAID
c. Cetirizine
d. Furosemide
Propranolol
Individual drug variation can result from pharmacokinetic and pharmacodynamic differences and may also be categorized as idiosyncratic. Which of the following statements provides an example of a pharmacodynamic effect?
a. Metabolism by liver enzyme CYP3A4
b. Protein binding to albumin
c. Sedation from blocking histamine 1 receptor
d. Increased distribution
c. Sedation from blocking histamine 1 receptor
Which one of the following med is more likely to be association w the development of anaphylactic shock?
a. Clozapine
b. Valproic acid
c. Sulfamethoxazole trimethoprim (bactrim)
d. Penicillin (pen VK)
d. Penicillin (pen VK)
During dental procedure which drugs should you avoid in pt w history of asthma?
a. Aspirin
b. Opiates
c. Antihistamines
d. All of the above
d. All of the above
Which of the following neuromuscular blockers is classified as depolarizing paralytic?
a. Pancuronium
b. Rocuronium
c. Succinylcholine
d. Vecuronium
c. Succinylcholine
Grapefruit juice inhibitor of which liver enzyme
a. Cyp2d6
b. cyp3A4
c. Cyp2c9
d. Cyp2b19
b. cyp3A4
Ventricular repolarization represented on the ECG by the
a. P wave
b. PR interval
c. QRS complex
d. T wave
d. T wave
Which of the following agent is a phosphodiesterase 3 inhibitor
a. Dobutamine
b. Dopamine
c. Milirinone
d. Phenylephrine
c. Milirinone
Which of the following is an example of an irreversible indirect acting cholinergic agent?
a. Sarin
b. Donepezil
c. Galantamine
d. Rivastigmine
a. Sarin
Toxin induced cell damage from drug metabolites can occur through a series of noncovalent and covalent interactions. Which one of the following is considered a noncovalent type of interaction
a. Exposed hepatocytes resulting in hepatoxicity
b. Increase protein resulting in nephrotoxicity
c. Increased build up of glutathione
d. Formation of hydrogen peroxide
d. Formation of hydrogen peroxide
A patient present to the dental clinic for routine cleaning. The pt complains of extreme dry mouth and feeling sleepy. You review the medication profile, which one of the following medications is most likely to result in dry mouth and sedation due to pharmacodynamic based receptor effects at the histamine receptor?
a. Diphenhydramine, benadryl
b. Sertraline (zoloft), depression
c. Propranolol, blood pressure medication
d. Valproic acid, anti seizure medication
a. Diphenhydramine, benadryl - allergy med this is what I found too
What are the 3 endogenous catecholamines?
a. Norepinephrine, dopamine, epinephrine
b. Dopamine, vasopressin, phenylephrine
c. Norepinephrine, dobutamine, epinephrine
d. Dobutamine, vasopressin, norepinephrine
a. Norepinephrine, dopamine, epinephrine
Which of the following results from covalent modification and alteration of DNA?
a. Teratogenicity
b. Mutagenesis
c. Carcinogenicity
d. Cardiotoxicity
b. Mutagenesis