Important Info 1.9 Flashcards
All preganglionic autonomic releases
ACh
Postganglionic parasympathetic releases
ACh
Postganglionic sympathetic releases
NE
If you have dry mouth, what receptor do you want to target
M3
Which of the following drugs has the greatest risk of causing orthostatic hypotension?
Terazosin
Which of the following drugs has anticholinergic side effects such as dry mouth
Lidocaine
dont think we learned this
What part of the EKG is ventricular repolarization
T wave
Irreversible indirect acting cholinergic
Sarin
Regeneration of AchE
Pralidoxime
What would not be fixed by atropine
Paralysis
First line agent for someone that has been exposed to nerve gas
Pralidoxidine (not correct)
- it is atropine
Quaternary amine
Glycopyrrolate
What would a pt not have if having cholinergic toxicity
Dry mouth
Depolarizing neuromuscular blocker
Succinylcholine
Which relieves angina without changing HR or BP
Ranolazine
Which one increases intracellular cGMP
Isosorbide Mononitrate
What breaks down Ach in the blood
AchE
Which alpha agonist causes orthostatic __
Alpha one; hypotension
Which of the following does beta 1 NOT do
Bronchodilation
Which of the following does beta 2 do
Bronchodilation
Know alpha 1 effects
In a pt with anaphylaxis, what do you give them
0.3 mg of IM epi
Alpha 1 agonist that helps with short term hypotension and nasal decongestion
Phenylephrine
Which is a PDE 3 inhibitor
Milrinone
The L in LOT stands for
Lorazepam
Short acting beta 2 agonist for asthma
Albuterol
What do you not use in asthmatic patients
a.Aspirin, NSAIDS
b.Opiates
c.Antihistamines
d.All of the above
all of the above
Aspirin and coumadin adverse effect
Bleeding
What beta blocker should you give an asthmatic patient
Metaprolol (beta 1 selective)
Drug variation can be classified as idiosyncratic, pharmokinetic, or ____
pharmodynamic
Different outcomes with same concentration and same outcome with different concentrations for drug variation
???
Lipid distribution increases as you age because of
increased body fat
What phase of metabolism is not prone to aging
phase 2
In pregnancy patients, they have increased CO and ___ GFR and ____ RBF
increased, increased
Non-covalent modification is depletion of glutathione. What does this do?
Disrupts cell defense
Anti-epileptic that causes gingival hyperplasia
Phenytoin
How many mutations do you have to have for malignancy?
More than 1
Teratogens are detrimental and cause cell division issues during
Blastocyte formation
Phase III is caused by
K+ movement
Product of CO
SV x HR
What class does Na+ fall under
Class I
Class IV are selective for myocardium
Nondihydropyridine
What drug causes dry mouth
Disopyramides
What drug inhibits the Na/K ATPase
Digoxin
Which one is not a part of acute coronary syndromes?
a. Stable ischemic heart disease
b. STEMI
c. NSTEMI
d. Unstable
a. Stable ischemic heart disease
More than 100 bpm is
tachycardia
Allergic reactions are often dose independent and not related to the drugs MOA
True
When someone an adverse effect to a drug how do you fix it?
Dose reduction
A drug that inhibits gastric emptying
Slows absorption
Which of the following are endogenous catecholamines
NE, epi, dopamine
Epinephrine is produced by the adrenal medulla and is released directly into the bloodstream. This makes epi a ______
Hormone
