Immunosuppresants and Cancer Chemotherapy Flashcards
1
Q
Immunosuppresants work by?
A
- inhibiting cytokine (IL-2) production or action
2. inhibiting DNA or RNA synthesis
2
Q
cyclosporine is a?
A
cytokine production inhibitor
3
Q
Tacrolimus is used in?
A
rheumatoid arthritis
4
Q
cyclosporine adverse effects?
A
- nephrotoxicity!
- high BP
- Tremors
- Hirutism
5
Q
glucocorticoids are drugs that?
A
inhibit cytokine gene expression
6
Q
what is the most important endogenous glucocorticoid?
A
cortisol
7
Q
example of a glucocorticoid?
A
prednisone
8
Q
Considerations for all immunosupressants?
A
- kidney or liver failure
- hypertension
- concurrent radiation therapy
9
Q
Most Cancer chemotherapy drugs affect?
A
cell division
10
Q
Cancer chemotherapy drugs have a?
A
narrow therapeutic index
11
Q
Example of a cancer chemotherapy cytotoxic drug?
A
alkylating agents
12
Q
mechanism of alkylating agents?
A
drug forms chemical bonds to DNA, thus inhibiting DNA replication and causing cell death
