Anti-inflamatory Drugs Flashcards
What is the mechanism of action of NSAIDS
they inhibit cyclooxyrgenase which inhibits prostaglandins from forming
How do NSAIDs act as an antipyretic?
they reduce fever by inhibiting prostaglandin E2 within the hypothalamus
what is the standard NSAID
Aspirin (Acetylsalicylic acid)
ASA is different than other NSAIDS because?
it causes irreversible inhibition of the COX enzyme
ASA is the only NSAID that can produce a?
anti platelet effect
How is ASA an anti platelet drug?
it irreversibly inhibits thromboxin A2 (what makes platelets sticky) for the life time of the platelet (about 8 days)
ASA is contraindicated in?
pregnancy and breast feeding
Reyes syndrome
occurs when children with influenza or chickenpox take ASA. Can cause vomiting, liver damage, and CNS problems
Adult signs of salicylate toxicity
tinnitus and hearing loss
child signs of salicylate toxicity
hyperventilation and CNS effects
what is the biggest problem with all NSAIDS
ulcers
what is an example of a selective COX-2 inhibitor?
celeoxib
what is an adverse effect of celecoxib?
increased risk for MI or stroke
what is used alongside NSAIDs to reduce GI ulceration?
misoprostol
what must the nurse assess for before giving NSAIDs
GI lesions or peptic ulcer disease and bleeding disorders
salicylates are never to be given to anyone?
under the age of 12 due to Reyes syndrome
what is allopurinol?
it is an antigout agent that is used to prevent attacks. It prevents production of uric acid
what is clochecine?
it is an antigout agent used for acute attacks because it reduces inflammatory response to the deposit of urate crystals
probenecid
increases the excretion of uric acid in the urine to treat gout
allopurinol needs to be taken?
on an ongoing basis
allopurinol is a?
xanthine oxidase inhibitor
which medication is most commonly used to treat rheumatoid arthritis?
methotrexate
acetominophen has?
little to no anti inflammatory effects
does acetaminophen act on the periphery?
no, it only acts centrally
