Anti-inflamatory Drugs

Question 1

What is the mechanism of action of NSAIDS

Answer 1

they inhibit cyclooxyrgenase which inhibits prostaglandins from forming

Question 2

How do NSAIDs act as an antipyretic?

Answer 2

they reduce fever by inhibiting prostaglandin E2 within the hypothalamus

Question 3

what is the standard NSAID

Answer 3

Aspirin (Acetylsalicylic acid)

Question 4

ASA is different than other NSAIDS because?

Answer 4

it causes irreversible inhibition of the COX enzyme

Question 5

ASA is the only NSAID that can produce a?

Answer 5

anti platelet effect

Question 6

How is ASA an anti platelet drug?

Answer 6

it irreversibly inhibits thromboxin A2 (what makes platelets sticky) for the life time of the platelet (about 8 days)

Question 7

ASA is contraindicated in?

Answer 7

pregnancy and breast feeding

Question 8

Reyes syndrome

Answer 8

occurs when children with influenza or chickenpox take ASA. Can cause vomiting, liver damage, and CNS problems

Question 9

Adult signs of salicylate toxicity

Answer 9

tinnitus and hearing loss

Question 10

child signs of salicylate toxicity

Answer 10

hyperventilation and CNS effects

Question 11

what is the biggest problem with all NSAIDS

Answer 11

ulcers

Question 12

what is an example of a selective COX-2 inhibitor?

Answer 12

celeoxib

Question 13

what is an adverse effect of celecoxib?

Answer 13

increased risk for MI or stroke

Question 14

what is used alongside NSAIDs to reduce GI ulceration?

Answer 14

misoprostol

Question 15

what must the nurse assess for before giving NSAIDs

Answer 15

GI lesions or peptic ulcer disease and bleeding disorders

Question 16

salicylates are never to be given to anyone?

Answer 16

under the age of 12 due to Reyes syndrome

Question 17

what is allopurinol?

Answer 17

it is an antigout agent that is used to prevent attacks. It prevents production of uric acid

Question 18

what is clochecine?

Answer 18

it is an antigout agent used for acute attacks because it reduces inflammatory response to the deposit of urate crystals

Question 19

probenecid

Answer 19

increases the excretion of uric acid in the urine to treat gout

Question 20

allopurinol needs to be taken?

Answer 20

on an ongoing basis

Question 21

allopurinol is a?

Answer 21

xanthine oxidase inhibitor

Question 22

which medication is most commonly used to treat rheumatoid arthritis?

Answer 22

methotrexate

Question 23

acetominophen has?

Answer 23

little to no anti inflammatory effects

Question 24

does acetaminophen act on the periphery?

Answer 24

no, it only acts centrally

Question 25

what is the maximum acetominophen dose for an adult?

Answer 25

4000mg per day

Question 26

what are the contraindications of acetominophen?

Answer 26

• severe hepatic or renal disease
• alcoholism
• drug allergy

Question 27

what is the hallmark of acetominophen toxicity?

Answer 27

hepatic necrosis

Question 28

what is the recommended antidote for acetominophen overdose?

Answer 28

acetylcysteine