Anti-coagulants + Anti-platelet Drugs Flashcards
What is the antidote for heparin?
protamine sulphate
What is the prototype for LMWHs?
Enoxaparin
Do LMWHs require lab monitoring?
no
Warfarin is strongly contraindicated in?
pregnancy
Anticoagulants are used?
prophylactically to prevent clots
How does Wafarin work?
it is a vitamin K antagonist and it will cause the liver to make less clotting factors.
Wafarin sodium is given _____ only
orally
The effects of warfarin may take up to?
3-5 days
Heparin acts?
immediately
Warfarin is monitored by?
prothrombin time
INR
used to monitor warfarin and corrects lab-to-lab variability
INR too high = ?
reduce dose
PT must be _____ the normal (control level)?
1.3 to 1.5 times
Normal target INR range is ____ control?
2-3 times the control
what is a food-drug interaction of warfarin?
food that contain Vitamin K
What is the best way to achieve a consistent effect of warfarin?
Keep vitamin K levels constant
What is the prototype for direct thrombin inhibitors?
Dabigatran
What is the prototype of direct factor Xa inhibitors?
rivaroxaban
what is the greatest adverse effects of ALL anticoagulants?
Increased risk of bleeding
What are the 2 examples of anti platelet drugs?
ASA and clopidogrel
clopidogrel is an irreversible…?
ADP receptor blocker
Antiplatelet agents are used to?
prevent clots
What is the lowest effective dose of ASA for anti platelet effects?
81 mg per day
Aspirin + clopidogrel combination…?
produces additive anti platelet activity BUT causes increased bleeding potential.
