Acid-Controlling Drugs

Question 1

The parietal cells of the stomach secrete?

Answer 1

Hydrochloric acid

Question 2

what is the primary site of action for acid-controlling drugs?

Answer 2

parietal cells

Question 3

ECL cells

Answer 3

secrete histamine and stimulate parietal cells

Question 4

What is the pH of the stomach?

Answer 4

1-2

Question 5

Which bacteria could cause ulcers?

Answer 5

H. pylori

Question 6

What is the prototype of H2 antagonists?

Answer 6

Cimetidine

Question 7

Cimetidine inhibits..?

Answer 7

liver cytochrome P-450 enzymes. Therefore affects metabolism of other drugs causing increased drug levels

Question 8

Cimetidine is used cautiously in people with?

Answer 8

impaired renal or liver function and patients who are confused, elderly or disoriented.

Question 9

Cimetidine should be taken?

Answer 9

1 hour before or after antacids

Question 10

PPIs inhibit?

Answer 10

the pump that moves hydrogen into the stomach lumen

Question 11

Is the action of PPIs reversible or irreversible?

Answer 11

irreversible

Question 12

what is the prototype of PPIs?

Answer 12

Omeprazole

Question 13

Omeprazole can cause increased bleeding when taken with?

Answer 13

Warfarin

Question 14

Omeprazole is enteric coated which means it should not be?

Answer 14

crushed, opened, or chewed

Question 15

Antacids do not..?

Answer 15

prevent acid production, but simply neutralize acid

Question 16

Aluminum hydroxide can often cause?

Answer 16

constipation

Question 17

Magnesium salts commonly cause?

Answer 17

diarrhea

Question 18

Magnesium salts are dangerous when used with?

Answer 18

renal failure

Question 19

Calcium salts may cause?

Answer 19

constipation

Question 20

TUMS are?

Answer 20

Calcium salts

Question 21

Sodium bicarbonate has a?

Answer 21

short duration of action

Question 22

Clients with HF or hypertension should?

Answer 22

use low-sodium antacids

Question 23

Sucralfate is a?

Answer 23

cytoprotective agent

Question 24

Sucralfate can only work in?

Answer 24

Low pH environments, therefore it needs to be taken before antacids

Question 25

Misoprostol cannot be used in?

Answer 25

pregnancy

Question 26

Main indication of PPIs?

Answer 26

short term treatment of active duodenal ulcers and benign gastric ulcers

Question 27

Most medications should be given ______ after giving an antacid?

Answer 27

1-2 hours

Question 28

Antacids may cause premature dissolving of?

Answer 28

enteric coated tablets

Question 29

Administer antacids with at least?

Answer 29

240 mL of water to ensure dispersion

Question 30

Misoprostol is a synthetic..?

Answer 30

prostaglandin

Question 31

Cytoprotective activity of prostaglandins?

Answer 31

production of mucus and bicarbonate