Acid-Controlling Drugs Flashcards
The parietal cells of the stomach secrete?
Hydrochloric acid
what is the primary site of action for acid-controlling drugs?
parietal cells
ECL cells
secrete histamine and stimulate parietal cells
What is the pH of the stomach?
1-2
Which bacteria could cause ulcers?
H. pylori
What is the prototype of H2 antagonists?
Cimetidine
Cimetidine inhibits..?
liver cytochrome P-450 enzymes. Therefore affects metabolism of other drugs causing increased drug levels
Cimetidine is used cautiously in people with?
impaired renal or liver function and patients who are confused, elderly or disoriented.
Cimetidine should be taken?
1 hour before or after antacids
PPIs inhibit?
the pump that moves hydrogen into the stomach lumen
Is the action of PPIs reversible or irreversible?
irreversible
what is the prototype of PPIs?
Omeprazole
Omeprazole can cause increased bleeding when taken with?
Warfarin
Omeprazole is enteric coated which means it should not be?
crushed, opened, or chewed
Antacids do not..?
prevent acid production, but simply neutralize acid
Aluminum hydroxide can often cause?
constipation
Magnesium salts commonly cause?
diarrhea
Magnesium salts are dangerous when used with?
renal failure
Calcium salts may cause?
constipation
TUMS are?
Calcium salts
Sodium bicarbonate has a?
short duration of action
Clients with HF or hypertension should?
use low-sodium antacids
Sucralfate is a?
cytoprotective agent
Sucralfate can only work in?
Low pH environments, therefore it needs to be taken before antacids