Immunology 8 - Case studies in immunology Flashcards

1
Q

What are the clinical features of anaphylaxis?

A

IS AWFUL HARD:

Itch (palms, soles, genitalia)
Stridor (due to laryngeal obstruction)

Angiodema (of lips and mucous membranes)
Wheeze (due to bronchoconstriction)
Flushing
Urticaria
Loss of Consciousness

Hypotension
Arrhythmias
Rhinorrhoea
D&V

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2
Q

Once someone has had an anaphylactic reaction, how should the cause be identified?

A

IgE blood test (skin prick should not be used)

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3
Q

What is “serum sickness”?

A

is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash, joint pain, fever, and lymphadenopathy. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III)

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4
Q

Around how long after exposure does serum sickness develop?

A

3 days

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5
Q

Recall some symptoms of serum sickness

A

IgG deposits in:

  • Joints (causing arthralgia)
  • Kidney (causing AKI)
  • Skin (causing a vasculitic rash)
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6
Q

How should serum sickness be managed?

A

Remove allergen
Corticosteroids
Manage fluids

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