Histology - Integument

Question 1

Answer 1

Meissner’s corpuscles - located in dermal papillae

Question 2

Answer 2

HD - hemidesmosome, A - focal adhesion, B - basal cell, L - lamina lucida, D - lamina densa, C - collagen type III (reticular fibrils), F - anchoring fibrils, I - intermediate filaments

Question 2

Answer 2

Stratum spinosum with cytoplasmic processes connected by desmosomes (at the light level called nodes of Bizzozero). Mitotically inactive, vitamin D production.

Question 3

Answer 3

Hair follice with internal and external root sheath, glassy membrane, cortex labeled.

Question 3

Answer 3

KG - keratohyalin granule in the stratum granulosum, the “grainy” third layer of the epidermis, involved in keratinization.

Question 4

Answer 4

Basal Lamina - above Stratum Basale.

Question 5

Answer 5

Langerhan’s Cell - note Birbeck granules (arrows), indented nucleus,and tonofilaments (T)

Question 6

Answer 6

Melanocyte with melanin granules, surrounded by kerotinocytes

Question 7

Answer 7

Reticular layer - Dermis. Dense irregular connective tissue, closely packedthick collagen fibers (type I), thick elastic fibers.

Question 9

Answer 9

malignant melanoma - no desmosomes, so high potential for metastasis

Question 11

Answer 11

Reticular layer - Dermis. Dense irregular connective tissue, closely packed thick collagen fibers (type I).

Question 12

Answer 12

Eccrine sweat glands - Narrow lumen, ACh innervation. Widely distributed. Merocrine Secretion.

Question 13

Answer 13

Stratum Corneum - the outermost layer of the epidermis, consisting of dead cells (corneocytes).

A barrier to protect underlying tissue from infection, dehydration, chemicals and mechanical stress. Desquamation, the process of cell shedding from the surface of the stratum corneum, balances proliferating keratinocytes that form in the stratum basale.

Question 14

Answer 14

Melanocyte, cytoplasmic extensinos, and melanin granules

Question 15

Answer 15

Pacinian Corpuscle - deep in integumen, deep vibration sensation

Question 16

Answer 16

Stratum Spinosum. D - Desmosome. Desmosome lies within cytoplasmic extensions, anchoring SS to neighboring keratinocytes. Also has desmosomes (nodes of Bizzozero). Mitotically inactive.

Question 17

Answer 17

Merkel cells - tactile, neural crest derived, located in stratum basale

Question 18

Answer 18

Apocrine sweat glands - Wide lumen. Merocrine secretion. Protein-rich product. Adrenergic innervation. Axilla, anus, external genetalia.

Question 19

Answer 19

rod-shaped Birbeck granules

Question 20

Answer 20

Melanocytes with no discernable nucleus, unlike keratinocytes in stratum basale above.

Question 21

Answer 21

Hair follice with extenral, internal root sheath labeled, cuticle, glassy membrane.

Answer 22

High magnification eccrine sweat gland with dark cells (D), clear cells (C ) adjacent to intercellular canaliculi (IC), and myoepthelial (My) cells that contract to assist in secretion.

Question 23

Answer 23

Sebaceous gland. Branched acinar gland in hair follicle that uses holocrine secretion to secrete sebum.