Hemorrhage Flashcards

1
Q

name 5 causes of hemorrhage

A
  • trauma
  • aneurysms
  • erosion; microbes, neoplasia
  • vitamin deficiency (eg. vit K involved in clotting)
  • thrombocytopenia (low platelets -> people on chemotherapeutics)
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2
Q

clinical significance of hemorrhage is dependent on what 3 things?

A
  • volume of blood loss
  • rate of blood loss
  • location of hemorrhage
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3
Q

what is bleeding into thorax called?

A

hemothorax

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4
Q

what is ripping of heart and bleeding into pericardium called?

A

hemopericardium

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5
Q

what is hemoperitoneum?

A

bleeding into peritoneum

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6
Q

what is hemarthrosis?

A

bleeding in a joint

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7
Q

what is hematoma?

A

bleeding into a tissue (non-specific)

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8
Q

what is purpura?

A

multiple hemorrhages <1cm

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9
Q

what is the most common purpura in children?

A

Henoch-Schonlein Purpura

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10
Q

what is the name for purpura in older adults?

A

senile purpura

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11
Q

what is the name for a common skin bruise

A

ecchymosis

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12
Q

what are 2 other names for petechiae?

A

pinpoint/splinter hemorrhage

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13
Q

an ascending aortic aneurism would cause what type of hemorrhage?

A

hemopericardium

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14
Q

an abdominal aortic aneurism would cause what type of hemorrhage?

A

hemoperitoneum

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15
Q

name 3 examples of hemorrhages in the skin?

A

purpura
ecchymosis
petechiae

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16
Q

what causes petechiae?

A

rapid increase in intercapillary P
(eg. valsalva maneuver, choking someone, gastritis w/vomitting)

17
Q

what is idiopathic (autoimmune) thrombocytopenic purpura (ITP)?

A

syndrome in which antibodies against platelet or megakaryocytic antigens cause thrombocytopenia

18
Q

what is the clinical presentation of acute ITP in children?

A
  • sudden onset of petechiae and purpura but are otherwise asymptomatic (may have frequent nose bleeds)
  • Spontaneous recovery occurs within 6 months in over 80% of cases
19
Q

what is a rare major threat for ITP (idiopathic thrombocytopenic purpura)?

A

intracranial hemorrhage

20
Q

what is the clinical presentation of chronic ITP in adults?

A
  • bleeding episodes, such as epistaxis, menorrhagia or ecchymoses
  • excessive bleeding after and minor procedures (eg. tooth extraction)
21
Q

what is the most common X-linked inherited bleeding disorder?

A

hemophilia A (factor VIII Deficiency)

22
Q

how do patients with Hemophilia A present?

A
  • mild, moderate, or severe bleeding tendencies
  • hematuria (bleed into bladder), intestinal obstruction, respiratory obstruction may occur with bleeding into respective organs
23
Q

what is the most frequent complication of hemophilia A?

A

degenerative joint disease caused by repeated bleeding into many joints

24
Q

In Hemophilia A, what was formerly the most common cause of death which is now largely prevented by treatment?

A

bleeding into the brain

25
Q

hemophilia B is an X-linked inherited disorder of deficiency of what clotting factor?

A

IX

26
Q

clotting factor IX is a vitamin ____-dependent protein made in the liver

A

K

27
Q

what are the bleeding manifestations of hemophilia B?

A

similar to hemophilia A

28
Q

what can’t you make if you are vitamin K deficient?

A

you cant make a fibrin plug

29
Q

what is von Willebrand disease?

A

heterogeneous complex of hereditary bleeding disorders related to deficiency or abnormality of vWF (von willebrand factor)

30
Q

most cases of vWD entail only a mild bleeding diathesis, except for what type?

A

type III

31
Q

what is the presenting symptom of von Willebrand disease?

A

excessive hemorrhage after trauma or surgery

32
Q

what life-threatening complication may occur in patients with type III vWD?

A

life-threating hemorrhage from the gut; hemarthroses like those in hemophilia are not unusual

33
Q

what would the laboratory diagnosis of ITP be?

A

low platelet count

34
Q

hemophilia A is a deficiency in what clotting factor?

A

VIII
(“hemophilia AAAAAAte”)

35
Q

what is the laboratory diagnosis for hemophilia A and B?

A

deficient in clotting factors VIII or IX

36
Q

how does von willebrand disease compare to hemophilia?

A

patients with vWD show immediate, mucocutaneous bleeding such as easy bruising, epstaxis, GI bleeding, and (in women) menorrhagia