Hematopoietic drugs

Question 1

Epoetin Alfa (Erythropoietin) MOA?

Answer 1

Stimulates production of RBCs

Question 2

Eopetin Alfa uses?

Answer 2

anemia

Question 3

What lab should be checked prior to Epoetin Alfa administration?

Answer 3

Hgb level should be <10-11 mg/dL

Question 4

High risk patients for Epoetin Alfa?

Answer 4

uncontrolled HTN or patients w/ cancer of myeloid origin

Question 5

What should you monitor for after administration of Epoetin Alfa?

Answer 5

HTN, autoimmune pure red-cell aplasia (very rare), cardiac arrest, hypotension, heart failure, stroke and MI

Question 6

Which drug is a long acting analog of eopetin alfa?

Answer 6

Darbepoetin alfa (Aranesp)

Question 7

Filgrastim (Neupogen) MOA?

Answer 7

granulocyte colony stimulating growth factor

Question 8

Uses of Filgrastim (Neupgen)?

Answer 8

neutropenia, mobilization of hematopoietic progenitor cells into peripheral blood for collection, and to increase neutrophil count in cancer patients

Question 9

Routes for Filgrastim (Neupogen)?

Answer 9

IV or IM

Question 10

Adverse effects of Filgrastim (Neupogen)?

Answer 10

bone pain and leukocytosis